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Orphenadrine Citrate ER
Orphenadrine Citrate ER (extended-release) is a muscle relaxant used to relieve pain and discomfort associated with muscle spasms. It is often prescribed as part of a comprehensive treatment plan that includes rest, physical therapy, and other medications. Orphenadrine works by acting on the central nervous system to reduce muscle tension.
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Frequently Asked Questions
How quickly does Orphenadrine Citrate ER work?
Patients may begin to notice relief from muscle spasms within 1 to 2 hours after taking the medication.
Can I take Orphenadrine Citrate ER with food?
Yes, it can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Orphenadrine Citrate ER?
There are no specific dietary restrictions while using Orphenadrine Citrate ER.
Is Orphenadrine Citrate ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Orphenadrine Citrate ER during these periods.
Comprehensive Drug Guide
How Does Orphenadrine Citrate ER Work?
Orphenadrine works by blocking the action of acetylcholine, a neurotransmitter involved in muscle contractions. This results in decreaseds muscle tone and relaxation of skeletal muscles. Additionally, it may have mild analgeic effects due to its central nervous system activity.
Common Dosages
- Extended-Release Tablets: Common strength includes 100 mg.
Typical Dosing
- The usual recommended dose is 100 mg taken orally twice daily, with or without food, or as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
Muscle Spasms: for the relief of discomfort associated with acute musculoskeletal conditions.
Who Shouldn't Take Orphenadrine Citrate ER?
- Known hypersensitivity to orphenadrine or any component of the formulation.
- Narrow-angle glaucoma.
- Myasthenia gravis.
- Severe urinary retention.
Advice From The Pharmacist
- Take Orphenadrine Citrate ER exactly as prescribed, and do not exceed the recommended dose.
- Be cautious about engaging in activities that require full alertness, such as driving or operating machinery, as it can cause drowsiness.
- Inform your healthcare provider about any other medications you are taking, as orphenadrine may interact with other CNS depressants.
Side Effects of Orphenadrine Citrate ER
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Blurred vision
- Constipation
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Confusion or hallucinations.
Risks and Warnings of Orphenadrine Citrate ER
- CNS Depression: Monitor for signs of excessive sedation, especially in older adults or those taking other CNS depressants.
- Anticholinergic Effects: Be cautious in patients with conditions exacerbated by anticholinergic medications, such as glaucoma or prostatic hypertrophy.
Interactions with Orphenadrine Citrate ER
Common Drug Interactions
- CNS Depressants: Use with caution when combined with alcohol, opioids, or sedatives, as this may enhance sedative effects.
- Other Anticholinergic Drugs: Be aware of additive anticholinergic effects when used with other medications that have anticholinergic properties.
Alternatives to Orphenadrine Citrate ER
- Other Muscle Relaxants: Such as cyclobenzaprine or tizanidine for similar indications.
- Physical Therapy: Non-pharmacological interventions may also help manage muscle spasms.
