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Orencia ClickJect

Orencia ClickJect (abatacept) is a biologic medication used for the treatment of moderate to severe rheumatoid arthritis in adults and juvenile idiopathic arthritis in children. It works by modulating the immune system to help reduce inflammation and joint damage associated with these autoimmune conditions.

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Frequently Asked Questions

How quickly does Orencia ClickJect work?
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Patients may begin to notice improvements in their symptoms within a few weeks, but optimal effects can take several months.

Can I take Orencia ClickJect with food?
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Yes, Orencia can be administered with or without food.

What should I do if I miss a dose?
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If you miss a dose, administer it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.

Is Orencia ClickJect safe during pregnancy?
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Consult your healthcare provider before using Orencia during pregnancy to evaluate potential risks and benefits.

What are the signs of serious side effects to watch for?
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Monitor for signs of severe allergic reactions or infections, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Orencia ClickJect Work?

Abatacept works by inhibiting the activation of T-cells, a type of white blood cell that plays a critical role in the immune response. By blocking the necessary signals for T-cell activation, Orencia helps to reduce inflammation and the immune response that contributes to the symptoms of rheumatoid arthritis.

Common Dosages

  • Subcutaneous injection: Common strengths include 125 mg/0.89 mL in prefilled syringes or pens.

Typical Dosing

  • For adults with rheumatoid arthritis: The usual dose is 125 mg administered once weekly, starting with an initial loading dose based on body weight.
  • For juvenile idiopathic arthritis: Dosing is based on weight and is usually administered once weekly.


Typical Dosing

FDA Approved Indications

  • Treatment of rheumatoid arthritis in adults.
  • Treatment of juvenile idiopathic arthritis in pediatric patients aged 2 years and older.


Who Shouldn't Take Orencia ClickJect?

  • Known hypersensitivity to abatacept or any component of the formulation.
  • Active infections, particularly serious infections like tuberculosis.


Advice From The Pharmacist

  • Administer Orencia ClickJect exactly as prescribed, and follow the recommended schedule for injections.
  • Monitor for signs of infection, as the medication can increase the risk of serious infections.
  • Store Orencia in the refrigerator, and allow it to reach room temperature before injection.


Side Effects of Orencia ClickJect

Common Side Effects

  • Injection site reactions (redness, itching, swelling)
  • Headache
  • Upper respiratory infections
  • Nausea


Uncommon/Severe Side Effects

  • Serious infections (pneumonia, sepsis)
  • Allergic reactions (rash, swelling, difficulty breathing)


Risks and Warnings of Orencia ClickJect

  • Infection Risk: Patients should be screened for latent infections, such as tuberculosis, before starting Orencia. Regular monitoring is advised.
  • Immunosuppression: Because Orencia modulates the immune system, it may increase susceptibility to infections.


Interactions with Orencia ClickJect

Common Drug Interactions

  • Other Immunosuppressive Agents: Use caution when combining with other immunosuppressive therapies, as this may further increase the risk of infections.
  • Vaccinations: Live vaccines should be avoided during treatment with Orencia.

Alternatives to Orencia ClickJect

  • Other Biologics: Such as adalimumab (Humira) or etanercept (Enbrel) for similar indications in rheumatoid arthritis.
  • Conventional DMARDs: Such as methotrexate or sulfasalazine.