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Odefsey
Odefsey is a combination antiretroviral medication used to treat HIV-1 infection in adults and children who weigh at least 35 kg. It contains rilpivirine, emtricitabine, and tenofovir alafenamide, which work together to reduce the amount of HIV in the blood (viral load) and help the immune system function better. Odefsey is often prescribed as a single-tablet regimen for individuals who have either never taken HIV medications before or are replacing an existing HIV treatment.
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Frequently Asked Questions
How long does it take for Odefsey to start working?
Odefsey begins lowering the viral load soon after starting treatment, but full benefits are typically seen within several weeks. Regular follow-ups with your healthcare provider are necessary to monitor viral load and treatment effectiveness.
Can I stop taking Odefsey once my viral load is undetectable?
No, Odefsey must be taken long-term to maintain viral suppression. Stopping the medication can lead to an increase in viral load and potential drug resistance.
What should I do if I miss a dose of Odefsey?
If you miss a dose, take it as soon as you remember, unless it is close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Can Odefsey cure HIV?
No, Odefsey does not cure HIV, but it helps manage the infection by lowering the viral load to undetectable levels, which reduces the risk of transmission and slows disease progression.
Is Odefsey safe during pregnancy?
Odefsey may be used during pregnancy, but it is important to discuss potential risks and benefits with your healthcare provider. Regular monitoring during pregnancy is essential to ensure both maternal and fetal health.
Comprehensive Drug Guide
How Does Odefsey Work?
Odefsey works by targeting the reverse transcriptase enzyme, which HIV uses to replicate itself. Rilpivirine (NNRTI) directly inhibits the enzyme, while emtricitabine and tenofovir alafenamide (NRTIs) incorporate themselves into the viral DNA, causing faulty replication. This combination of mechanisms helps lower the viral load in the blood, reducing the ability of the virus to spread and damage the immune system.
Common Dosages
- Single-tablet regimen: 25 mg rilpivirine, 200 mg emtricitabine, and 25 mg tenofovir alafenamide
Typical Dosing
- Take one tablet once daily with food.
- It is important to take the tablet at the same time every day to maintain consistent drug levels in the body.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in adults and children weighing at least 35 kg who are either treatment-naive or virologically suppressed on a stable antiretroviral regimen.
Who Shouldn't Take Odefsey?
- Known hypersensitivity to rilpivirine, emtricitabine, tenofovir alafenamide, or any component of the formulation.
- Severe liver impairment (Child-Pugh Class C).
- Concurrent use of proton pump inhibitors (PPIs) such as omeprazole, as these can reduce the effectiveness of rilpivirine.
Advice From The Pharmacist
- Take Odefsey with food to ensure proper absorption of rilpivirine.
- Avoid taking antacids or H2 receptor antagonists (such as ranitidine) at the same time as Odefsey. If necessary, take antacids 2 hours before or 4 hours after Odefsey, and H2 blockers at least 12 hours before or 4 hours after the dose.
- Do not miss doses. Missing doses can increase the risk of viral resistance. If you miss a dose, take it as soon as you remember unless it’s close to the next dose.
- Regular blood tests may be necessary to monitor kidney function, liver function, and viral load.
Side Effects of Odefsey
Common Side Effects
- Headache
- Fatigue
- Nausea
- Dizziness
Uncommon/Severe Side Effects
- Lactic acidosis (a buildup of lactic acid in the blood, which can be life-threatening)
- Severe liver problems, especially in individuals with hepatitis B or C
- Kidney problems (reduced kidney function)
- Depression or mood changes
Risks and Warnings of Odefsey
- Lactic Acidosis and Liver Problems: Odefsey can cause lactic acidosis and severe liver issues, particularly in individuals with pre-existing liver conditions. Patients should be monitored for symptoms like fatigue, nausea, abdominal pain, and jaundice.
- Kidney Function: Tenofovir alafenamide can affect kidney function, so kidney function tests may be needed before and during treatment.
- Hepatitis B Reactivation: In patients co-infected with HIV and hepatitis B, stopping Odefsey may lead to a flare-up of hepatitis B. Close monitoring is required if treatment is discontinued.
Interactions with Odefsey
Common Drug Interactions
- Proton pump inhibitors (e.g., omeprazole): These reduce the effectiveness of rilpivirine and should not be taken with Odefsey.
- Antacids and H2 receptor antagonists: Must be taken at different times to avoid reducing the absorption of rilpivirine.
- Rifampin and rifabutin: These drugs may lower the levels of rilpivirine in the blood.
- St. John’s Wort: Can reduce the effectiveness of Odefsey and should be avoided.
Alternatives to Odefsey
- Genvoya®: A single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide.
- Biktarvy®: A single-tablet regimen containing bictegravir, emtricitabine, and tenofovir alafenamide.
- Complera®: A similar combination tablet containing rilpivirine, emtricitabine, and tenofovir disoproxil fumarate.
