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Nuplazid
Nuplazid (pimavanserin) is an atypical antipsychotic specifically approved for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. It is unique among antipsychotics in that it does not exacerbate motor symptoms in Parkinson's disease patients.
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Frequently Asked Questions
How quickly does Nuplazid work?
Patients may start to notice improvements in psychotic symptoms within a week, but it may take longer to see full benefits.
Can I take Nuplazid with other medications?
Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Nuplazid safe during pregnancy?
Nuplazid should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions, worsening psychosis, or changes in mood and behavior, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Nuplazid Work?
Nuplazid works primarily as a selective serotonin inverse agonist at the 5-HT2A receptor. By selectively targeting this receptor, it helps to alleviate psychotic symptoms without significantly impacting the dopaminergic system, which is crucial for movement in patients with Parkinson's disease.
Common Dosages
- Tablets: 34 mg.
Typical Dosing
- Adults: The usual recommended dosage is 34 mg taken orally once daily, with or without food. Dosage adjustments may be made based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of hallucinations and delusions associated with Parkinson's disease psychosis.
Who Shouldn't Take Nuplazid?
- Known hypersensitivity to pimavanserin or any component of the formulation.
Advice From The Pharmacist
- Take Nuplazid exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider.
- Monitor for any changes in mood, behavior, or worsening of psychotic symptoms, and report these to your healthcare provider immediately.
Side Effects of Nuplazid
Common Side Effects
- Confusion
- Hallucinations
- Nausea
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Increased risk of mortality in elderly patients with dementia-related psychosis
Risks and Warnings of Nuplazid
- Elderly Patients: Nuplazid is not approved for the treatment of patients with dementia-related psychosis due to an increased risk of mortality.
- Monitoring: Regular follow-up appointments are necessary to monitor efficacy and any side effects, especially in patients with Parkinson's disease.
Interactions with Nuplazid
Common Drug Interactions
- CYP450 Enzyme Interactions: Nuplazid is metabolized by CYP3A4, so caution is advised when used with strong inducers or inhibitors of this enzyme, as they may affect drug levels.
Alternatives to Nuplazid
- Other Antipsychotic Medications: Such as quetiapine or clozapine, though these may have a greater impact on motor symptoms.
- Non-pharmacological Interventions: Cognitive-behavioral therapies may also help manage psychotic symptoms.
