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NitroMist
NitroMist (nitroglycerin) is a sublingual spray formulation used primarily for the acute relief of angina pectoris (chest pain) associated with coronary artery disease. It acts as a vasodilator, helping to improve blood flow to the heart muscle and reduce the workload on the heart.
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Frequently Asked Questions
How quickly does NitroMist work?
NitroMist typically provides relief within 1 to 3 minutes after administration.
Can I use NitroMist with food?
Yes, it can be used with or without food, but ensure the spray is administered under the tongue for optimal absorption.
What should I do if I miss a dose?
NitroMist is used as needed; if you have not taken it for acute angina, use it when symptoms occur.
Is NitroMist safe during pregnancy?
Consult your healthcare provider before using NitroMist during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for symptoms such as severe allergic reactions or significant drops in blood pressure, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does NitroMist Work?
Nitroglycerin works by releasing nitric oxide, which relaxes the smooth muscle in blood vessels. This action leads to the dilation of both arterial and venous blood vessels, decreasing myocardial oxygen demand and relieving angina symptoms.
Common Dosages
- Sublingual spray: Common strength is 0.4 mg per spray.
Typical Dosing
- For acute angina: Spray 1 dose (0.4 mg) under the tongue as needed at the first sign of chest pain. If symptoms persist after 5 minutes, a second dose may be taken. Do not exceed 3 doses within 15 minutes.
- For prevention: Use as directed by your healthcare provider before activities that may provoke angina.
Typical Dosing
FDA Approved Indications
- Acute relief of angina pectoris.
- Prevention of angina attacks due to physical exertion or emotional stress.
Who Shouldn't Take NitroMist?
- Known hypersensitivity to nitroglycerin or any component of the formulation.
- Severe anemia, hypotension, or right ventricular infarction.
- Use of phosphodiesterase inhibitors (e.g., sildenafil) within 24-48 hours.
Advice From The Pharmacist
- Use NitroMist exactly as prescribed, and ensure the spray is properly aimed under the tongue for effective absorption.
- Store the spray at room temperature and protect it from moisture and heat.
- Seek medical attention if chest pain persists after the second dose or if you experience any severe side effects.
Side Effects of NitroMist
Common Side Effects
- Headache
- Dizziness
- Flushing
- Nausea
- Hypotension (low blood pressure)
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Syncope (fainting)
Risks and Warnings of NitroMist
- Blood Pressure Monitoring: Regularly monitor blood pressure, especially if you have a history of hypotension.
- Tolerance: Prolonged use can lead to tolerance, which may require adjustments in therapy.
Interactions with NitroMist
Common Drug Interactions
- Phosphodiesterase Inhibitors: Avoid using NitroMist with these medications, as they can lead to severe hypotension.
- Other Vasodilators: Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Alternatives to NitroMist
- Other Nitrates: Such as isosorbide dinitrate or isosorbide mononitrate for long-term management of angina.
- Beta-blockers: For angina prevention by reducing heart workload.
