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Nitrolingual
Nitrolingual (nitroglycerin) is a vasodilator medication used primarily for the relief of angina pectoris (chest pain) associated with coronary artery disease. It works by relaxing the blood vessels, allowing for improved blood flow and reduced heart workload.
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Frequently Asked Questions
How quickly does Nitrolingual work?
Nitrolingual typically provides relief within 1 to 3 minutes after administration.
Can I use Nitrolingual with food?
Yes, it can be used with or without food, but ensure the spray is administered under the tongue for best results.
What should I do if I miss a dose?
Nitrolingual is used as needed; if you have not taken it for acute angina, use it when symptoms occur.
Is Nitrolingual safe during pregnancy?
Consult your healthcare provider before using Nitrolingual during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for symptoms such as severe allergic reactions or significant drops in blood pressure, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Nitrolingual Work?
Nitroglycerin works by releasing nitric oxide in the body, which leads to the relaxation of smooth muscle in blood vessels. This action results in the dilation of both arterial and venous blood vessels, decreasing myocardial oxygen demand and alleviating angina symptoms.
Common Dosages
- Sublingual spray: Common strength is 0.4 mg per spray.
- Sublingual tablets: Available in 0.3 mg and 0.6 mg strengths.
Typical Dosing
- For acute angina: Spray 1 dose (0.4 mg) under the tongue as needed, at the first sign of chest pain. If symptoms persist after 5 minutes, a second dose may be taken. Do not exceed 3 doses within 15 minutes.
- For prevention: Use as directed by your healthcare provider before activities that may provoke angina.
Typical Dosing
FDA Approved Indications
- Acute relief of angina pectoris.
- Prevention of angina attacks due to physical exertion or emotional stress.
Who Shouldn't Take Nitrolingual?
- Known hypersensitivity to nitroglycerin or any component of the formulation.
- Severe anemia, hypotension, or right ventricular infarction.
- Use of phosphodiesterase inhibitors (e.g., sildenafil) within 24-48 hours.
Advice From The Pharmacist
- Use Nitrolingual exactly as prescribed, and ensure the spray is properly aimed under the tongue for effective absorption.
- Store the spray at room temperature and keep it away from moisture and heat.
- Seek medical attention if chest pain persists after the second dose or if you experience any severe side effects.
Side Effects of Nitrolingual
Common Side Effects
- Headache
- Dizziness
- Flushing
- Hypotension (low blood pressure)
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Syncope (fainting)
Risks and Warnings of Nitrolingual
- Blood Pressure Monitoring: Monitor blood pressure regularly, especially if you have a history of hypotension.
- Tolerance: Long-term use can lead to tolerance, which may require dose adjustments.
Interactions with Nitrolingual
Common Drug Interactions
- Phosphodiesterase Inhibitors: Avoid concurrent use with these medications, as they can lead to severe hypotension.
- Other Vasodilators: Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Alternatives to Nitrolingual
- Other Nitrates: Such as isosorbide dinitrate or isosorbide mononitrate for long-term management of angina.
- Beta-blockers: For angina prevention by reducing heart workload.
