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Nisoldipine ER
Nisoldipine ER is a calcium channel blocker used primarily for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain). It works by relaxing the blood vessels, which helps to lower blood pressure and improve blood flow to the heart.
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Frequently Asked Questions
How quickly does nisoldipine ER work?
Nisoldipine ER may start to lower blood pressure within 1 to 2 hours, but it may take several weeks for the full effects to be seen.
Can I take nisoldipine ER with food?
Yes, nisoldipine ER can be taken with or without food, but consistency is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using nisoldipine ER?
There are no specific dietary restrictions while using nisoldipine ER, but limit grapefruit juice consumption.
Is nisoldipine ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using nisoldipine ER during these periods.
Comprehensive Drug Guide
How Does Nisoldipine ER Work?
Nisoldipine works by selectively inhibiting calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to relaxation of the smooth muscle in blood vessels, resulting in vasodilation, decreased peripheral resistance, and lower blood pressure.
Common Dosages
- Extended-Release Tablets: 8 mg and 16 mg.
Typical Dosing
- The usual starting dose for adults is 8 mg once daily, which may be adjusted based on blood pressure response. The maximum recommended dose is 16 mg per day.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure.
- Angina Pectoris: for the management of chest pain due to angina.
Who Shouldn't Take Nisoldipine ER?
- Known hypersensitivity to nisoldipine or any component of the formulation.
- Severe hypotension (low blood pressure).
- Aortic stenosis or heart failure.
Advice From The Pharmacist
- Take nisoldipine ER exactly as prescribed, and do not crush or chew the extended-release tablets.
- Monitor blood pressure regularly to ensure effectiveness and adjust the dosage as necessary.
- Be cautious when engaging in activities that require alertness, as nisoldipine may cause dizziness.
Side Effects of Nisoldipine ER
Common Side Effects
- Headache
- Dizziness
- Flushing
- Peripheral edema (swelling of the limbs)
- Fatigue
Uncommon/Severe Side Effects
- Severe hypotension
- Worsening angina
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of Nisoldipine ER
- Hypotension: Monitor blood pressure closely, especially when starting treatment or adjusting doses.
- Heart Function: Use with caution in patients with heart failure or significant aortic stenosis.
Interactions with Nisoldipine ER
Common Drug Interactions
- Other Antihypertensives: Use caution when combined with other medications that lower blood pressure.
- Grapefruit Juice: May increase the levels of nisoldipine; avoid excessive consumption.
Alternatives to Nisoldipine ER
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for managing hypertension and angina.
- ACE Inhibitors: As alternative antihypertensive options.
