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niCARdipine HCl
niCARdipine HCl is a calcium channel blocker primarily used for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain). It works by relaxing blood vessels, which improves blood flow and decreases the heart's workload.
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Frequently Asked Questions
How quickly does niCARdipine HCl work?
niCARdipine HCl may start to lower blood pressure within 1 to 2 hours, but it may take several weeks for the full effects to be seen.
Can I take niCARdipine HCl with food?
Yes, niCARdipine HCl can be taken with or without food; however, consistency is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using niCARdipine HCl?
There are no specific dietary restrictions, but it is advisable to limit grapefruit juice.
Is niCARdipine HCl safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using niCARdipine HCl during these periods.
Comprehensive Drug Guide
How Does niCARdipine HCl Work?
niCARdipine works by blocking calcium entry into vascular smooth muscle and cardiac muscle cells, leading to relaxation of smooth muscle, vasodilation, and decreased peripheral vascular resistance. This results in lower blood pressure and reduced angina symptoms.
Common Dosages
- Immediate-Release Capsules: 20 mg, 30 mg, and 40 mg.
- Extended-Release Tablets: 30 mg, 60 mg, and 90 mg.
Typical Dosing
- For hypertension: The usual starting dose is 20 mg to 30 mg taken orally three times daily for immediate-release forms. For extended-release formulations, the initial dose may be 30 mg once daily.
- For angina: Dosage may be adjusted based on individual response and clinical condition.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure.
- Angina Pectoris: for the management of chronic stable angina.
Who Shouldn't Take niCARdipine HCl?
- Known hypersensitivity to niCARdipine or any component of the formulation.
- Severe hypotension (low blood pressure).
- Aortic stenosis or unstable angina.
Advice From The Pharmacist
- Take niCARdipine HCl exactly as prescribed, and do not crush or chew extended-release tablets.
- Monitor blood pressure regularly to ensure effectiveness and adjust the dosage as necessary.
- Be cautious when engaging in activities that require alertness, as niCARdipine may cause dizziness.
Side Effects of niCARdipine HCl
Common Side Effects
- Headache
- Dizziness
- Flushing
- Peripheral edema (swelling of the limbs)
- Fatigue
Uncommon/Severe Side Effects
- Severe hypotension
- Worsening angina
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of niCARdipine HCl
- Hypotension: Monitor blood pressure closely, especially when starting treatment or adjusting doses.
- Heart Function: Use with caution in patients with heart failure or significant aortic stenosis.
Interactions with niCARdipine HCl
Common Drug Interactions
- Other Antihypertensives: Use caution when combined with other medications that lower blood pressure.
- Grapefruit Juice: May increase the levels of niCARdipine; avoid excessive consumption.
Alternatives to niCARdipine HCl
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for managing hypertension and angina.
- ACE Inhibitors: As alternative antihypertensive options.
