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Nexletol

Nexletol (generic name: bempedoic acid) is a medication used to lower low-density lipoprotein (LDL) cholesterol in adults with elevated cholesterol levels. It is typically prescribed for patients who have not achieved sufficient cholesterol control with diet and exercise alone, or for those who are unable to tolerate statin therapy. Nexletol works by inhibiting an enzyme involved in cholesterol synthesis in the liver.



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Frequently Asked Questions

How quickly does Nexletol work?
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Patients may begin to see a reduction in LDL cholesterol levels within 4 to 8 weeks of starting treatment.

Can I take Nexletol with food?
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Yes, Nexletol can be taken with or without food.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using Nexletol?
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There are no specific dietary restrictions while using Nexletol, but maintaining a heart-healthy diet is encouraged.

Is Nexletol safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Nexletol during these periods.

Comprehensive Drug Guide

How Does Nexletol Work?

Bempedoic acid inhibits ATP citrate lyase, an enzyme that plays a crucial role in the production of cholesterol in the liver. By reducing cholesterol synthesis, Nexletol leads to decreased levels of LDL cholesterol in the bloodstream.



Common Dosages

  • Tablets: 180 mg.

Typical Dosing

  • The usual dosage for adults is 180 mg taken orally once daily. It can be taken with or without food.


Typical Dosing

FDA Approved Indications

  • Primary Hyperlipidemia: as an adjunct to diet and exercise for the treatment of adult patients with elevated LDL cholesterol.


Who Shouldn't Take Nexletol?

  • Known hypersensitivity to bempedoic acid or any component of the formulation.
  • Active liver disease or unexplained persistent elevations in liver transaminases.


Advice From The Pharmacist

  • Take Nexletol exactly as prescribed, and do not exceed the recommended dosage.
  • Monitor cholesterol levels regularly to assess the effectiveness of the treatment.
  • Maintain a heart-healthy diet and exercise routine while taking this medication.


Side Effects of Nexletol

Common Side Effects

  • Muscle spasms
  • Back pain
  • Abdominal pain
  • Elevated liver enzymes


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, itching, swelling)
  • Tendon rupture (although rare).


Risks and Warnings of Nexletol

  • Liver Function: Regular monitoring of liver enzymes is recommended, especially during the initial treatment period.
  • Muscle-Related Effects: Be aware of the potential for muscle-related side effects, and report any unexplained muscle pain or weakness to your healthcare provider.


Interactions with Nexletol

Common Drug Interactions

  • Statins: May be used in conjunction with statins, but monitoring for additive effects on muscle and liver function is advised.
  • Other Cholesterol-Lowering Medications: Consult your healthcare provider for specific recommendations regarding concurrent use.


Alternatives to Nexletol

  • Statins: Such as atorvastatin or simvastatin for managing cholesterol levels.
  • Other Non-Statin Options: Such as ezetimibe or PCSK9 inhibitors for patients who require additional cholesterol-lowering.