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Nevirapine ER
Nevirapine ER (extended-release) is an antiretroviral medication used in the treatment of HIV-1 infection. It belongs to the class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Nevirapine helps reduce the viral load in the body, which can improve immune function and reduce the risk of developing AIDS-related illnesses.
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Frequently Asked Questions
How quickly does nevirapine ER work?
Nevirapine ER begins to work shortly after initiation, but it may take several weeks to see significant reductions in viral load.
Can I take nevirapine ER with food?
Yes, nevirapine can be taken with or without food; however, consistency is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using nevirapine ER?
There are no specific dietary restrictions while using nevirapine, but maintaining a balanced diet can support overall health.
Is nevirapine ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using nevirapine ER, as it is considered for use in these populations under certain circumstances.
Comprehensive Drug Guide
How Does Nevirapine ER Work?
Nevirapine works by binding to the reverse transcriptase enzyme, which is crucial for the replication of HIV. By inhibiting this enzyme, nevirapine prevents the virus from converting its RNA into DNA, effectively halting its ability to replicate and spread in the body.
Common Dosages
- Extended-Release Tablets: 400 mg.
Typical Dosing
- The usual starting dose for adults is 400 mg taken orally once daily, which may be adjusted based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- HIV-1 Infection: as part of a combination antiretroviral therapy for the treatment of HIV-1 infection in adults and pediatric patients.
Who Shouldn't Take Nevirapine ER?
- Known hypersensitivity to nevirapine or any component of the formulation.
- A history of severe liver disease or hepatic toxicity related to nevirapine.
Advice From The Pharmacist
- Take nevirapine exactly as prescribed, at the same time each day to maintain consistent blood levels.
- Monitor for any signs of rash, as serious skin reactions can occur; report any rash or other allergic symptoms to your healthcare provider immediately.
- Regular liver function tests may be required during treatment, especially in the first few months.
Side Effects of Nevirapine ER
Common Side Effects
- Rash
- Nausea
- Fatigue
- Headache
- Abdominal pain
Uncommon/Severe Side Effects
- Severe skin reactions (Stevens-Johnson syndrome)
- Liver toxicity (symptoms include jaundice, dark urine, or right upper quadrant pain)
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of Nevirapine ER
- Liver Toxicity: Monitor liver function regularly; nevirapine can cause severe liver injury, especially in women and patients with high CD4 counts at initiation.
- Rash: Risk of severe rash; inform patients about signs of skin reactions and when to seek medical help.
Interactions with Nevirapine ER
Common Drug Interactions
- Other Antiretrovirals: Caution should be taken when used with other antiretroviral medications that may affect liver enzymes.
- Hormonal Contraceptives: Nevirapine may reduce the effectiveness of hormonal contraceptives; alternative or additional contraceptive methods should be considered.
Alternatives to Nevirapine ER
- Other NNRTIs: Such as efavirenz or rilpivirine for managing HIV-1 infection.
- Combination Therapy: Often, nevirapine is part of a combination regimen with other antiretroviral drugs for enhanced efficacy.