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Neupro
Neupro (generic name: rotigotine) is a dopamine agonist used in the treatment of Parkinson’s disease and restless legs syndrome (RLS). It is delivered via a transdermal patch, allowing for continuous delivery of medication over a 24-hour period. This method helps manage symptoms by stimulating dopamine receptors in the brain.
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Frequently Asked Questions
How quickly does Neupro work?
Patients may begin to notice improvements in symptoms within 1 to 2 weeks of starting treatment, although full effects may take longer.
Can I take Neupro with food?
Yes, Neupro can be taken with or without food.
What should I do if I miss a dose?
If you miss applying a patch, apply it as soon as you remember. If it’s close to the time for your next patch, skip the missed application and continue with your regular schedule.
Are there any dietary restrictions while using Neupro?
There are no specific dietary restrictions while using Neupro.
Is Neupro safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Neupro during these periods.
Comprehensive Drug Guide
How Does Neupro Work?
Rotigotine works by directly stimulating dopamine receptors in the brain, mimicking the effects of naturally occurring dopamine. This helps to improve motor control and alleviate symptoms of both Parkinson's disease and RLS.
Common Dosages
- Transdermal Patch: Available in multiple strengths, including 2 mg/24 hours, 4 mg/24 hours, 6 mg/24 hours, 8 mg/24 hours, and 12 mg/24 hours.
Typical Dosing
- For Parkinson’s disease: The usual starting dose is 2 mg/24 hours, which may be gradually increased based on individual response, with a maximum dose of 8 mg/24 hours.
- For RLS: The initial dose is typically 1 mg/24 hours, with possible titration based on efficacy and tolerability.
Typical Dosing
FDA Approved Indications
- Parkinson’s Disease: for the treatment of the signs and symptoms of Parkinson’s disease.
- Restless Legs Syndrome (RLS): for the treatment of moderate to severe primary RLS.
Who Shouldn't Take Neupro?
- Known hypersensitivity to rotigotine or any component of the formulation.
- Severe hepatic impairment.
Advice From The Pharmacist
- Apply Neupro to a clean, dry area of skin on the upper body or upper outer arm, avoiding areas with cuts or irritation.
- The patch should be replaced once every 24 hours; rotate application sites to minimize skin irritation.
- Monitor for side effects, especially during the initial titration phase.
Side Effects of Neupro
Common Side Effects
- Nausea
- Vomiting
- Dizziness or lightheadedness
- Skin reactions at the application site
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Uncontrolled movements (dyskinesia)
- Hallucinations or other psychiatric symptoms
Risks and Warnings of Neupro
- Dopaminergic Effects: Monitor for signs of excessive dopaminergic stimulation, including dyskinesia and psychiatric disturbances.
- Hypotension: Caution is advised for patients at risk of hypotension, especially when starting treatment or increasing the dose.
Interactions with Neupro
Common Drug Interactions
- Antihypertensive Agents: Increased risk of hypotension when used with blood pressure-lowering medications.
- Other Dopaminergic Drugs: Use with caution in conjunction with other medications that affect dopamine levels.
Alternatives to Neupro
- Other Dopamine Agonists: Such as pramipexole or ropinirole for treating Parkinson’s disease or RLS.
- Levodopa: A common alternative for managing Parkinson’s disease symptoms.
