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Neo-Polycin HC

Neo-Polycin HC (neomycin, polymyxin B, and hydrocortisone) is a topical antibiotic and anti-inflammatory medication used to treat bacterial infections of the skin and to reduce inflammation associated with those infections. It is commonly used for conditions such as otitis externa (outer ear infections) and other superficial skin infections.



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Frequently Asked Questions

How quickly will I see results with Neo-Polycin HC?
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Many patients notice improvement within a few days of starting treatment, but this can vary based on the severity of the infection.

Can I use Neo-Polycin HC for all types of skin infections?
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This product is specifically for bacterial infections and should not be used for viral or fungal infections.

What should I do if I miss a dose?
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If you miss a dose, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.

Is it safe to use Neo-Polycin HC during pregnancy?
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Consult your healthcare provider before using this medication during pregnancy to evaluate potential risks and benefits.

What are the signs of an allergic reaction to watch for?
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Monitor for symptoms such as rash, itching, swelling, or difficulty breathing, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Neo-Polycin HC Work?

  • Neomycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, effectively stopping the growth of bacteria.
  • Polymyxin B: A cationic detergent that disrupts the bacterial cell membrane, leading to cell lysis and death.
  • Hydrocortisone: A corticosteroid that reduces inflammation and alleviates symptoms such as redness, swelling, and itching.


The combination of these ingredients provides both antibacterial and anti-inflammatory effects, helping to control infections and their associated symptoms.



Common Dosages

  • Topical ointment: The formulation typically includes neomycin (as neomycin sulfate), polymyxin B, and hydrocortisone in specific concentrations.

Typical Dosing

  • Adults and children: Apply a thin layer of Neo-Polycin HC to the affected area(s) 2 to 3 times daily, or as directed by a healthcare provider. Cover with a sterile bandage if desired.

Typical Dosing

FDA Approved Indications

  • The treatment of bacterial infections of the skin where inflammation is also present.


Who Shouldn't Take Neo-Polycin HC?

  • Known hypersensitivity to any of the active ingredients or components of the formulation
  • Viral, fungal, or tuberculosis infections of the skin


Advice From The Pharmacist

  • Apply Neo-Polycin HC as directed, using a clean applicator to avoid contamination.
  • Wash your hands thoroughly before and after application.
  • Avoid contact with eyes and mucous membranes; if contact occurs, rinse thoroughly with water.
  • If symptoms do not improve within a few days or worsen, consult your healthcare provider.


Side Effects of Neo-Polycin HC

Common Side Effects

  • Local irritation (redness, itching, burning)
  • Dryness or peeling of the skin


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, itching, swelling)
  • Superinfection or overgrowth of non-susceptible organisms (e.g., fungi)


Risks and Warnings of Neo-Polycin HC

  • Allergic Reactions: Be vigilant for potential allergic reactions; discontinue use and seek medical attention if severe reactions occur.
  • Skin Sensitivity: Prolonged use may lead to increased skin sensitivity or irritation; monitor the treatment area and consult your healthcare provider if issues arise.


Interactions with Neo-Polycin HC

Common Drug Interactions

  • Other Topical Medications: Use with caution when applying other topical treatments in the same area, as they may interfere with the effectiveness of Neo-Polycin HC.


Alternatives to Neo-Polycin HC

  • Other Topical Antibiotics: Such as mupirocin or clindamycin for similar indications.
  • Oral Antibiotics: For more extensive infections or those that do not respond to topical treatments.