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Nendrux

Nendrux is a combination of lidocaine (a local anesthetic) and salicylic acid (a keratolytic agent) used topically to relieve pain and discomfort from conditions such as warts, calluses, corns, and minor skin irritations. Lidocaine numbs the skin by blocking nerve signals, while salicylic acid helps to exfoliate and remove dead skin cells, promoting healing of the affected area.



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Frequently Asked Questions

How long does it take for Nendrux to work?
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You may start feeling pain relief from the lidocaine component within 15 minutes of application. Skin conditions treated with salicylic acid, such as warts or corns, may take several days to weeks to see improvement.

Can I use Nendrux on open wounds?
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No, Nendrux should not be applied to open wounds or broken skin. Doing so can increase the risk of systemic absorption and lead to side effects.

Can I use Nendrux with other topical medications?
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It is important to consult your healthcare provider before combining Nendrux with other topical treatments, as this could increase the risk of skin irritation or other adverse effects.

How often should I apply Nendrux?
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The typical dosing is 1 to 2 times per day, depending on the severity of the condition. Always follow the directions given by your healthcare provider.

Can Nendrux be used for children?
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Nendrux should be used in children only under the supervision of a healthcare provider, and its use may be limited based on the child's age and the condition being treated.

Comprehensive Drug Guide

How Does Nendrux Work?

Lidocaine works by blocking sodium channels in the skin’s nerve endings, temporarily numbing the skin and reducing pain sensations. Salicylic acid breaks down the keratin in the outer layer of skin, softening and shedding dead skin cells, which helps to remove thickened skin and treat warts, corns, or calluses.



Common Dosages

  • Lidocaine 4% - 5% and salicylic acid 10% - 40%
  • Topical cream, ointment, gel, or patches

Typical Dosing

  • Apply a thin layer of the cream or ointment to the affected area 1 to 2 times daily as directed by a healthcare provider.
  • If using a patch, apply it to the clean, dry skin for the prescribed amount of time.


Typical Dosing

FDA Approved Indications

  • Topical pain relief for minor skin irritations
  • Wart, corn, and callus removal
  • Minor skin inflammation or injury


Who Shouldn't Take Nendrux?

  • Hypersensitivity to lidocaine, salicylic acid, or any other component of the formulation.
  • Severe skin infections or open wounds.
  • Severe liver disease (for lidocaine).
  • Salicylate allergy (for salicylic acid).


Advice From The Pharmacist

  • Avoid applying Nendrux to broken or irritated skin unless directed by a healthcare provider.
  • Do not apply to large areas of skin, as lidocaine can be absorbed and cause side effects if overused.
  • Be cautious about using Nendrux in combination with other topical medications, as this may increase irritation.
  • Wash hands thoroughly after applying the product.
  • If using a patch, ensure that the application site is clean and dry to avoid irritation or reduced effectiveness.


Side Effects of Nendrux

Common Side Effects

  • Mild skin irritation (redness, itching, or dryness)
  • Burning or stinging at the application site
  • Peeling or flaking of skin


Uncommon/Severe Side Effects

  • Allergic reactions (rash, swelling, difficulty breathing)
  • Severe skin irritation or blistering


Risks and Warnings of Nendrux

  • Lidocaine Toxicity: Overuse or application to large areas of the skin can result in systemic absorption, leading to symptoms such as dizziness, confusion, or seizures.
  • Salicylate Toxicity: Excessive use of salicylic acid can cause ringing in the ears or hearing loss, especially when used on large areas of skin or for prolonged periods.
  • Avoid Use on Open Wounds: Applying Nendrux to open or severely irritated skin can lead to increased absorption and potential side effects.


Interactions with Nendrux

Common Drug Interactions

  • Topical retinoids (e.g., adapalene): Can increase the risk of skin irritation when used together with salicylic acid.
  • Other local anesthetics (e.g., bupivacaine, mepivacaine): May increase the risk of lidocaine toxicity.
  • Salicylates (e.g., aspirin): Using additional salicylate-containing medications can increase the risk of salicylate toxicity.


Alternatives to Nendrux

  • Duofilm®: A topical solution for warts, containing salicylic acid.
  • Lidoderm®: A lidocaine patch used for local pain relief.
  • Salicylic Acid: Available in higher concentrations for wart removal.
  • Compound W®: A common OTC treatment for warts, corns, and calluses.