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Nardil

Nardil (phenelzine sulfate) is a monoamine oxidase inhibitor (MAOI) primarily used for the treatment of depression, particularly in cases of atypical depression. It may also be used for anxiety disorders, including social anxiety disorder.



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Frequently Asked Questions

How quickly does Nardil work?
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Patients may begin to notice improvements in their depressive symptoms within 2 to 4 weeks, but it may take longer to achieve optimal effects.

Can I take Nardil with food?
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You should avoid tyramine-rich foods while taking Nardil to prevent potential hypertensive crises.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.

Is Nardil safe during pregnancy?
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Nardil should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.

What are the signs of serious side effects to watch for?
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Monitor for signs of severe allergic reactions or hypertensive crises, and seek immediate medical attention if these occur.

Comprehensive Drug Guide

How Does Nardil Work?

Phenelzine works by inhibiting the enzyme monoamine oxidase, which is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By preventing this breakdown, Nardil increases the levels of these neurotransmitters, which helps improve mood and alleviate depressive symptoms.



Common Dosages

  • Tablets: Common strength is 15 mg.

Typical Dosing

  • Adults: The usual recommended starting dose is 15 mg taken orally three times a day, with gradual increases based on clinical response, up to a maximum of 60 mg per day.


Typical Dosing

FDA Approved Indications

  • Treatment of major depressive disorder.
  • Treatment of anxiety disorders.


Who Shouldn't Take Nardil?

  • Known hypersensitivity to phenelzine or any component of the formulation.
  • Severe liver disease.
  • History of certain conditions such as pheochromocytoma or concurrent use of other MAOIs.


Advice From The Pharmacist

  • Take Nardil exactly as prescribed and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
  • Follow a strict diet to avoid tyramine-rich foods (e.g., aged cheeses, cured meats), which can trigger hypertensive crises when taken with MAOIs.
  • Monitor for any changes in mood or behavior, especially during the initial treatment period.


Side Effects of Nardil

Common Side Effects

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Nausea
  • Weight gain


Uncommon/Severe Side Effects

  • Severe hypertensive crisis (symptoms may include severe headache, chest pain, and increased heart rate)
  • Liver damage
  • Allergic reactions (rash, itching, swelling)


Risks and Warnings of Nardil

  • Dietary Restrictions: Follow dietary restrictions strictly to avoid dangerous interactions with tyramine-rich foods.
  • Drug Interactions: Be cautious when combining with other medications, especially those that may increase serotonin levels.


Interactions with Nardil

Common Drug Interactions

  • Tyramine-rich Foods: Avoid foods high in tyramine to prevent hypertensive crises.
  • Other Medications: Inform your healthcare provider about all medications you are taking, especially those affecting the central nervous system or metabolic pathways.


Alternatives to Nardil

  • Other Antidepressants: Such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) for similar indications.
  • Psychotherapy: Cognitive behavioral therapy (CBT) or other therapeutic approaches may also be considered.