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Modafinil
Modafinil is a stimulant medication primarily used to promote wakefulness in individuals with excessive sleepiness due to conditions such as narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It is also sometimes used off-label for enhancing cognitive function and concentration.
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Frequently Asked Questions
How quickly does modafinil work?
Patients typically begin to feel the effects of modafinil within 1 to 2 hours after taking the medication.
Can I take modafinil with food?
Yes, modafinil can be taken with or without food, although taking it with food may delay its onset of action slightly.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember on the same day. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using modafinil?
There are no specific dietary restrictions while using modafinil, but maintaining a balanced diet can support overall health.
Is modafinil safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using modafinil, as its safety during these periods is not fully established.
Comprehensive Drug Guide
How Does Modafinil Work?
The exact mechanism of action of modafinil is not fully understood. It is thought to work by influencing various neurotransmitters in the brain, including increasing dopamine levels and affecting histamine and norepinephrine pathways. This results in increased alertness and reduced fatigue.
Common Dosages
- Tablets: 100 mg and 200 mg.
Typical Dosing
- For narcolepsy and obstructive sleep apnea: The usual recommended dose is 200 mg taken orally once daily in the morning.
- For shift work sleep disorder: The usual dose is 200 mg taken approximately 1 hour before the start of the work shift.
Typical Dosing
FDA Approved Indications
- Narcolepsy: for the treatment of excessive daytime sleepiness.
- Obstructive Sleep Apnea: as an adjunct treatment to improve wakefulness in patients with excessive sleepiness.
- Shift Work Sleep Disorder: to improve wakefulness in individuals who work non-traditional hours.
Who Shouldn't Take Modafinil?
- Known hypersensitivity to modafinil or any component of the formulation.
- A history of serious skin reactions or allergic reactions to other medications.
Advice From The Pharmacist
- Take modafinil exactly as prescribed, and do not adjust the dosage without consulting your healthcare provider.
- Avoid taking modafinil close to bedtime, as it may interfere with sleep.
- Monitor for side effects, and report any severe reactions, such as skin rash or breathing difficulties, to your healthcare provider.
Side Effects of Modafinil
Common Side Effects
- Headache
- Nausea
- Dizziness
- Insomnia
- Anxiety
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Serious skin reactions (Stevens-Johnson syndrome)
- Cardiovascular effects (e.g., increased heart rate or blood pressure).
Risks and Warnings of Modafinil
- Serious Skin Reactions: There is a risk of serious skin reactions, including Stevens-Johnson syndrome; patients should be monitored for any rash or skin changes.
- Cardiovascular Monitoring: Use with caution in individuals with a history of heart problems or hypertension.
- Mental Health Effects: Modafinil may exacerbate anxiety or cause mood changes; patients should be monitored for these effects.
Interactions with Modafinil
Common Drug Interactions
- CYP450 Inhibitors and Inducers: Modafinil is metabolized by the liver; drugs that affect liver enzymes (such as certain anticonvulsants and rifampin) can alter its effects.
- Other CNS Stimulants: Caution should be exercised when combining with other stimulants, as this may increase the risk of side effects.
Alternatives to Modafinil
- Other Stimulants: Such as amphetamines or armodafinil may be considered for similar indications in promoting wakefulness.
- Lifestyle Modifications: Such as improved sleep hygiene or cognitive-behavioral therapy for managing sleep disorders.
