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Metoprolol-hydroCHLOROthiazide
Metoprolol-hydrochlorothiazide is a combination medication that includes metoprolol, a beta-adrenergic blocker, and hydrochlorothiazide, a thiazide diuretic. This combination is primarily used to treat hypertension (high blood pressure), helping to lower blood pressure and reduce the risk of cardiovascular events.
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Frequently Asked Questions
How quickly does metoprolol-hydrochlorothiazide work?
Patients may start to see effects on blood pressure within 1 to 2 hours, with optimal control typically established within several days.
Can I take metoprolol-hydrochlorothiazide with food?
Yes, it can be taken with or without food, but consistency is important for optimal absorption.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using metoprolol-hydrochlorothiazide?
There are no specific dietary restrictions, but monitoring salt intake may be beneficial due to the diuretic effect.
Is metoprolol-hydrochlorothiazide safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using this medication.
Comprehensive Drug Guide
How Does Metoprolol-hydroCHLOROthiazide Work?
- Metoprolol: Selectively blocks beta-1 adrenergic receptors in the heart, leading to decreased heart rate and myocardial contractility, which helps lower blood pressure.
- Hydrochlorothiazide: Inhibits sodium reabsorption in the distal convoluted tubules of the kidneys, promoting diuresis (increased urine production) and helping to reduce blood volume, which further lowers blood pressure.
Common Dosages
- Tablets: 50 mg/25 mg, 100 mg/25 mg, and other combinations depending on the formulation.
Typical Dosing
- The usual recommended starting dose is 50 mg/25 mg once daily, which may be adjusted based on blood pressure response, with a maximum daily dose of 100 mg/25 mg.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure in adults.
Who Shouldn't Take Metoprolol-hydroCHLOROthiazide?
- Known hypersensitivity to metoprolol, hydrochlorothiazide, or any component of the formulation.
- Severe bradycardia (slow heart rate) or advanced atrioventricular block.
- Severe renal impairment or anuria (inability to urinate).
Advice From The Pharmacist
- Take the medication exactly as prescribed and do not discontinue suddenly without consulting your healthcare provider, as this can lead to rebound hypertension.
- Monitor blood pressure regularly and report any significant changes to your healthcare provider.
- Be cautious of potential dizziness or lightheadedness, especially when standing up quickly.
Side Effects of Metoprolol-hydroCHLOROthiazide
Common Side Effects
- Fatigue
- Dizziness
- Nausea
- Headache
- Increased urination
Uncommon/Severe Side Effects
- Severe hypotension (low blood pressure)
- Bradycardia (slow heart rate)
- Electrolyte imbalances (especially low potassium levels).
Risks and Warnings of Metoprolol-hydroCHLOROthiazide
- Bradycardia: Monitor heart rate; dosage adjustments may be necessary if bradycardia occurs.
- Electrolyte Imbalances: Regular monitoring of electrolyte levels, particularly potassium, may be necessary.
- Caution in Asthma: Use with caution in patients with asthma or other respiratory conditions due to potential bronchoconstriction from beta-blockers.
Interactions with Metoprolol-hydroCHLOROthiazide
Common Drug Interactions
- CNS Depressants: Use caution when combining with other CNS depressants, as they may increase sedation.
- Other Antihypertensives: Monitor blood pressure closely if used in combination with other antihypertensive agents.
Alternatives to Metoprolol-hydroCHLOROthiazide
- Other Antihypertensive Combinations: Such as calcium channel blockers or ACE inhibitors combined with diuretics for managing hypertension.
- Single-Agent Therapy: Either metoprolol or hydrochlorothiazide alone may be considered based on individual patient needs.
