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Metdray
Metdray is the generic version of a biologic medication designed to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is classified as a tumor necrosis factor (TNF) inhibitor, a type of biologic therapy that targets inflammation at its source by blocking TNF, a protein responsible for driving inflammation in autoimmune diseases. Metdray helps reduce joint pain, swelling, and damage, improving the quality of life for individuals with chronic inflammatory conditions.
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Frequently Asked Questions
How long does it take for Metdray to start working?
Most patients begin to see improvements in their symptoms within the first 2-4 weeks of treatment, with more significant results after 12 weeks.
Can I administer Metdray myself?
Yes, Metdray is available in pre-filled syringes and auto-injectors that can be self-administered after receiving proper training from your healthcare provider.
What should I do if I miss a dose of Metdray?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
Can I take Metdray if I’m pregnant?
Metdray should only be used during pregnancy if the potential benefits outweigh the risks. Be sure to discuss this with your healthcare provider if you are pregnant or planning to become pregnant.
Are there any dietary restrictions while taking Metdray?
There are no specific dietary restrictions while taking Metdray. However, maintaining a healthy lifestyle and avoiding substances that may worsen your condition, such as alcohol, is recommended.
Comprehensive Drug Guide
How Does Metdray Work?
Metdray works by inhibiting tumor necrosis factor (TNF), a key protein that promotes inflammation in autoimmune diseases. By blocking TNF, Metdray reduces inflammation and the immune system's overactivity, preventing further joint damage and reducing the symptoms of autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Common Dosages
- Pre-filled syringes or auto-injectors: 50 mg, 100 mg
Typical Dosing
- For rheumatoid arthritis: The usual starting dose is 50 mg weekly or 100 mg every two weeks, depending on the patient’s response and physician recommendations.
- For psoriatic arthritis: 50 mg once a week, with adjustments as necessary.
- For ankylosing spondylitis: 50 mg weekly, following the same dosing as rheumatoid arthritis.
Typical Dosing
FDA Approved Indications
- Moderate to severe rheumatoid arthritis
- Psoriatic arthritis
- Ankylosing spondylitis
- Juvenile idiopathic arthritis
- Plaque psoriasis
Who Shouldn't Take Metdray?
- Known hypersensitivity to Metdray or any of its components
- Active infections, such as tuberculosis or hepatitis B
- Severe congestive heart failure
Advice From The Pharmacist
- Metdray is administered as a subcutaneous injection and can be self-administered at home with proper training.
- Patients should be screened for tuberculosis and other infections before starting treatment.
- Keep the medication in the refrigerator and allow it to reach room temperature before injecting.
- Regular monitoring for infections and allergic reactions is necessary during treatment.
- Avoid live vaccines while on Metdray, as the medication may affect the immune response.
Side Effects of Metdray
Common Side Effects
- Injection site reactions (redness, pain, swelling)
- Upper respiratory infections
- Headache
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Increased risk of serious infections, including tuberculosis and hepatitis B
- Liver problems, including elevated liver enzymes
- Exacerbation of congestive heart failure
Risks and Warnings of Metdray
- Infection Risk: Metdray suppresses the immune system, which may increase the risk of serious infections. Patients with a history of recurrent infections should be closely monitored.
- Hepatitis B Reactivation: Patients with a history of hepatitis B should be screened and monitored for reactivation during treatment.
- Congestive Heart Failure: Metdray may worsen symptoms of heart failure in certain patients, and its use should be carefully monitored in individuals with heart disease.
Interactions with Metdray
Common Drug Interactions
- Immunosuppressive drugs: Combining Metdray with other immunosuppressive medications may increase the risk of infections.
- Live vaccines: Patients should avoid receiving live vaccines while taking Metdray, as the immune system may not respond effectively, or there may be an increased risk of infection.
Alternatives to Metdray
- Humira (adalimumab): A TNF inhibitor used for treating similar autoimmune conditions like rheumatoid arthritis and psoriatic arthritis.
- Enbrel (etanercept): Another TNF inhibitor used for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
- Remicade (infliximab): A TNF inhibitor administered via intravenous infusion for Crohn’s disease, rheumatoid arthritis, and other autoimmune conditions.
- Methotrexate: A traditional disease-modifying antirheumatic drug (DMARD) used in combination with TNF inhibitors for better management of autoimmune conditions.
