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Mesalamine ER

Mesalamine ER (extended-release) is an anti-inflammatory medication primarily used in the treatment of ulcerative colitis and proctitis, conditions characterized by inflammation of the colon. It works by directly acting on the colonic mucosa to reduce inflammation and promote healing.

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Frequently Asked Questions

How quickly does mesalamine ER work?
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Patients may start to notice improvements in symptoms within a few weeks, but it may take longer to see full benefits.

Can I take mesalamine ER with food?
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Yes, mesalamine ER can be taken with or without food; however, taking it with food may help minimize gastrointestinal discomfort.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using mesalamine ER?
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There are no specific dietary restrictions, but maintaining a balanced diet can help manage symptoms

Is mesalamine ER safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using mesalamine ER.

Comprehensive Drug Guide

How Does Mesalamine ER Work?

Mesalamine works by inhibiting the production of inflammatory mediators in the gut, particularly through the inhibition of leukotriene synthesis and the scavenging of free radicals. This helps to reduce inflammation in the colon and promotes healing of the intestinal lining.



Common Dosages

  • Extended-Release Tablets: 800 mg or 1,200 mg.

Typical Dosing

  • For ulcerative colitis, the usual starting dose is 2.4 g to 4.8 g per day, divided into multiple doses, depending on the severity of the condition. For maintenance therapy, doses may be reduced.


Typical Dosing

FDA Approved Indications

  • Ulcerative Colitis: for the maintenance of remission and treatment of active disease.
  • Proctitis: for the treatment of inflammation of the rectum.


Who Shouldn't Take Mesalamine ER?

  • Known hypersensitivity to mesalamine or any component of the formulation.
  • History of gastrointestinal obstruction or significant renal impairment.


Advice From The Pharmacist

  • Take mesalamine ER as prescribed, with plenty of fluids, and do not crush or chew the tablets, as they are designed for extended release.
  • Monitor for side effects, particularly gastrointestinal symptoms, and report any severe reactions to your healthcare provider.


Side Effects of Mesalamine ER

Common Side Effects

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Headache


Uncommon/Severe Side Effects

  • Allergic reactions (rash, itching, swelling)
  • Kidney problems (symptoms include changes in urination)
  • Pancreatitis (symptoms include severe abdominal pain).


Risks and Warnings of Mesalamine ER

  • Renal Function: Monitor kidney function periodically, especially in patients with a history of renal issues.
  • Severe Allergic Reactions: Be aware of potential for hypersensitivity reactions; discontinue use if symptoms occur.
  • Gastrointestinal Effects: Use with caution in patients with a history of gastrointestinal obstruction or inflammatory bowel disease.


Interactions with Mesalamine ER

Common Drug Interactions

  • Other Gastrointestinal Medications: Be cautious when combining with other medications that may affect the gut, as they may alter mesalamine's effectiveness.


Alternatives to Mesalamine ER

  • Other 5-ASA Compounds: Such as sulfasalazine or balsalazide for similar indications.
  • Corticosteroids: For more severe inflammatory bowel disease to help manage flare-ups.