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Megestrol Acetate
Megestrol acetate is a progestin, a synthetic form of the hormone progesterone. It is primarily used to treat anorexia, cachexia, or significant weight loss in patients with conditions like cancer or AIDS. Megestrol acetate can stimulate appetite and promote weight gain.
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Frequently Asked Questions
How quickly does megestrol acetate work for weight gain?
Patients may begin to notice an increase in appetite and weight gain within a few weeks of starting treatment.
Can I take megestrol acetate with food?
Yes, megestrol acetate can be taken with or without food; taking it with food may help reduce gastrointestinal irritation.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using megestrol acetate?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable to support overall health.
Is megestrol acetate safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using megestrol acetate.
Comprehensive Drug Guide
How Does Megestrol Acetate Work?
Megestrol acetate works by binding to progesterone receptors, leading to changes in gene expression that can promote weight gain by stimulating appetite and altering metabolism. It can also have an antitumor effect in some cancer types.
Common Dosages
- Tablets: 20 mg and 40 mg.
- Oral Suspension: 125 mg/5 mL.
Typical Dosing
- For weight gain, the usual recommended dose is 400 mg to 800 mg per day, depending on the specific indication and the patient's needs.
- For cancer treatment, dosing may vary based on the regimen prescribed by the healthcare provider.
Typical Dosing
FDA Approved Indications
- Weight Gain: treatment of anorexia or cachexia in patients with cancer or AIDS.
- Hormonal Treatment: for certain types of breast and endometrial cancers.
Who Shouldn't Take Megestrol Acetate?
- Known hypersensitivity to megestrol or any component of the formulation.
- History of thromboembolic disorders or active arterial or venous thromboembolism.
Advice From The Pharmacist
- Take megestrol acetate exactly as prescribed, and do not adjust the dose without consulting your healthcare provider.
- Monitor for side effects, particularly changes in weight, mood, or signs of fluid retention.
- Regular follow-up appointments may be necessary to assess the effectiveness and monitor for potential side effects.
Side Effects of Megestrol Acetate
Common Side Effects
- Weight gain
- Increased appetite
- Fatigue
- Dizziness
- Hot flashes
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Liver dysfunction (elevated liver enzymes)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Megestrol Acetate
- Thromboembolic Events: There is an increased risk of thromboembolism, particularly in patients with a history of such events.
- Hormonal Effects: Megestrol acetate may cause changes in menstrual cycles and other hormonal effects; patients should be informed about these potential changes.
- Monitoring: Regular monitoring of weight, blood pressure, and liver function is recommended during treatment.
Interactions with Megestrol Acetate
Common Drug Interactions
- Anticoagulants: Megestrol acetate may increase the risk of thrombosis when used with blood thinners.
- Other Hormonal Treatments: Use caution when combining with other hormonal therapies.
Alternatives to Megestrol Acetate
- Appetite Stimulants: Other medications, such as dronabinol, may be considered for stimulating appetite.
- Nutritional Support: Dietary interventions and supplements can be used in conjunction with medications for weight gain.
