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Maxzide-25

Maxzide-25 is a combination medication that contains triamterene and hydrochlorothiazide. It is primarily used to treat hypertension (high blood pressure) and to manage edema (fluid retention) associated with conditions such as heart failure and certain kidney disorders. The combination of a potassium-sparing diuretic (triamterene) and a thiazide diuretic (hydrochlorothiazide) helps control blood pressure while minimizing potassium loss.

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Frequently Asked Questions

How quickly does Maxzide-25 work?
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Patients may start to see improvements in blood pressure within a few hours, but it may take several days to achieve optimal control.

Can I take Maxzide-25 with food?
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Yes, it is recommended to take Maxzide-25 with food to improve absorption and reduce gastrointestinal discomfort.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using Maxzide-25?
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There are no specific dietary restrictions, but monitoring potassium intake is advisable due to the risk of hyperkalemia.

Is Maxzide-25 safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Maxzide-25.

Comprehensive Drug Guide

How Does Maxzide-25 Work?

  • Hydrochlorothiazide works by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, leading to increased excretion of sodium and water, which helps lower blood pressure and reduce edema.
  • Triamterene acts on the renal tubules to inhibit sodium reabsorption while sparing potassium, thus reducing the risk of hypokalemia (low potassium levels) often associated with thiazide diuretics.

Common Dosages

  • Tablets: Each tablet contains 25 mg of hydrochlorothiazide and 37.5 mg of triamterene.

Typical Dosing

  • The usual recommended dose is one tablet taken once daily, preferably in the morning to avoid nocturia (frequent urination at night).


Typical Dosing

FDA Approved Indications

  • Hypertension: treatment of high blood pressure in adults.
  • Edema: management of fluid retention in patients with conditions such as heart failure or nephrotic syndrome.

Who Shouldn't Take Maxzide-25?

  • Known hypersensitivity to triamterene, hydrochlorothiazide, or any component of the formulation.
  • Anuria (failure of the kidneys to produce urine).
  • Severe renal impairment or electrolyte imbalance.


Advice From The Pharmacist

  • Take Maxzide-25 in the morning with food to improve absorption and reduce the risk of gastrointestinal upset.
  • Monitor your blood pressure regularly to assess the effectiveness of the medication.
  • Report any signs of electrolyte imbalances, such as muscle cramps, weakness, or irregular heartbeat.


Side Effects of Maxzide-25

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination
  • Gastrointestinal disturbances (nausea, diarrhea)


Uncommon/Severe Side Effects

  • Hyperkalemia (high potassium levels)
  • Severe allergic reactions (rash, itching, swelling)
  • Renal dysfunction


Risks and Warnings of Maxzide-25

  • Electrolyte Imbalances: Regular monitoring of electrolytes is recommended, especially potassium levels.
  • Kidney Function: Assess renal function periodically, particularly in patients with a history of kidney disease.
  • Blood Pressure Monitoring: Caution should be taken when transitioning from other antihypertensive medications.

Interactions with Maxzide-25

Common Drug Interactions

  • Other Diuretics: Use caution when combining with other diuretics due to the risk of dehydration and electrolyte imbalances.
  • Potassium Supplements: Avoid potassium supplements or potassium-rich foods unless prescribed, as Maxzide-25 may increase potassium levels.

Alternatives to Maxzide-25

  • Other Antihypertensives: Such as ACE inhibitors, ARBs, or calcium channel blockers for blood pressure management.
  • Different Diuretic Combinations: Such as other thiazide diuretics or loop diuretics depending on the clinical scenario.