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Marlissa
Marlissa is a combination oral contraceptive that contains two hormones: ethinyl estradiol (an estrogen) and levonorgestrel (a progestin). It is used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the lining of the uterus to prevent fertilization and implantation. Marlissa is also prescribed for managing menstrual cycle regulation, reducing the risk of ovarian cysts, treating acne, and managing heavy or painful periods.
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Frequently Asked Questions
How effective is Marlissa at preventing pregnancy?
When taken correctly, Marlissa is more than 99% effective at preventing pregnancy. However, missing pills or taking them inconsistently can reduce its effectiveness.
Can Marlissa help with acne?
Yes, Marlissa may help improve acne by regulating hormone levels that contribute to breakouts.
What should I do if I miss a pill?
If you miss one active pill, take it as soon as you remember. If you miss two or more pills, follow the instructions in the package insert, and use backup contraception (e.g., condoms) until you’ve taken active pills for 7 consecutive days.
Can Marlissa be used to skip periods?
Yes, some women use combination birth control pills to skip their periods by continuously taking the active pills and skipping the placebo week. Consult your healthcare provider for advice on how to do this safely.
Are there long-term risks with using Marlissa?
Long-term use of combination birth control pills may slightly increase the risk of certain conditions like blood clots and some cancers (breast and cervical). Regular check-ups with your healthcare provider are important to monitor for any potential risks.
Comprehensive Drug Guide
How Does Marlissa Work?
- Inhibition of ovulation: The hormones in Marlissa stop the ovaries from releasing an egg.
- Thickening of cervical mucus: This makes it more difficult for sperm to enter the uterus and fertilize an egg.
- Endometrial changes: The lining of the uterus is altered, making it less suitable for a fertilized egg to implant.
Together, these mechanisms provide effective birth control when taken correctly.
Common Dosages
- 21 active tablets: Containing 0.03 mg of ethinyl estradiol and 0.15 mg of levonorgestrel.
- 7 placebo tablets: Inactive pills taken during the last week of the cycle to allow for a withdrawal bleed (menstrual period).
Typical Dosing
- Take 1 active pill daily for 21 days, followed by 1 placebo pill daily for 7 days.
- It is important to take Marlissa at the same time every day for maximum effectiveness in preventing pregnancy.
Typical Dosing
FDA Approved Indications
- Preventing pregnancy
- Regulating menstrual cycles
- Treating acne
- Reducing the risk of ovarian cysts
- Managing heavy or painful periods (dysmenorrhea)
Who Shouldn't Take Marlissa?
rlissa should not be used in individuals with:
- A history of blood clots, deep vein thrombosis (DVT), or pulmonary embolism.
- Uncontrolled high blood pressure.
- Liver disease or liver tumors.
- Breast cancer or any hormone-sensitive cancer.
- Migraine headaches with aura.
- Known hypersensitivity to ethinyl estradiol or levonorgestrel.
- Smokers over the age of 35, due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Marlissa at the same time every day for best results. If you miss a dose, take it as soon as you remember, and follow the instructions in the package insert for multiple missed doses.
- Backup contraception (e.g., condoms) should be used if you miss more than one active pill or start the pack late, especially during the first cycle.
- Marlissa does not protect against sexually transmitted infections (STIs). Use condoms to reduce the risk of STIs.
- Some medications, such as antibiotics and antiepileptics, may decrease the effectiveness of Marlissa. Inform your healthcare provider of all medications you are taking.
Side Effects of Marlissa
Common Side Effects
- Nausea or vomiting
- Breast tenderness
- Headache
- Weight gain or bloating
- Mood changes
- Breakthrough bleeding or spotting
Uncommon/Severe Side Effects
- Blood clots (leg pain, swelling, shortness of breath)
- Stroke (sudden vision changes, difficulty speaking, or weakness on one side of the body)
- Liver problems (yellowing of the skin or eyes, severe abdominal pain)
- High blood pressure
Risks and Warnings of Marlissa
- Blood Clots: Combination birth control pills like Marlissa increase the risk of blood clots, especially in women who smoke, are overweight, or have a history of clotting disorders.
- Cardiovascular Risks: The risk of heart attack or stroke is higher in women over 35 who smoke. Women who smoke should consider other contraceptive methods.
- Liver Damage: Estrogen-containing contraceptives have been associated with liver damage and benign liver tumors.
- Cancers: There may be a slight increased risk of breast and cervical cancers with long-term use of hormonal contraceptives.
Interactions with Marlissa
Common Drug Interactions
- Antibiotics (e.g., rifampin): Can reduce the effectiveness of Marlissa.
- Antiepileptic drugs (e.g., carbamazepine, phenytoin): May decrease contraceptive efficacy.
- St. John’s Wort: May reduce the effectiveness of Marlissa, increasing the risk of unintended pregnancy.
- HIV medications: Some antiretrovirals may interact with hormonal contraceptives.
Alternatives to Marlissa
- Ortho Tri-Cyclen: Another combination oral contraceptive with a similar hormonal composition but varying hormone levels across the cycle.
- NuvaRing: A vaginal ring that delivers a continuous dose of hormones over a 3-week period, followed by a ring-free week.
- Depo-Provera: A progestin-only injectable contraceptive given every 3 months.
- IUDs (Mirena, Paragard): Long-term contraceptive devices that provide protection without daily adherence.
