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Lyrica CR
Lyrica CR (pregabalin) is an extended-release medication used to treat various conditions, including neuropathic pain, fibromyalgia, and generalized anxiety disorder. It is designed to provide prolonged relief from symptoms by releasing the active ingredient gradually over time.
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Frequently Asked Questions
Can I take pregabalin if I have kidney disease?
It's best to consult with your doctor. They may need to adjust your dosage because the drug is primarily cleared through the kidneys.
Does pregabalin cause weight gain?
It's possible. Some people do experience weight gain while taking pregabalin, especially if using it long-term.
I missed a dose of pregabalin, what should I do?
No worries! Take it as soon as you remember if it's not too close to the next dose. If it's almost time for your next dose, skip the missed one. Never double up on doses!
Can I just stop taking pregabalin abruptly?
No, it's advised against abruptly stopping pregabalin. Discontinuing suddenly can cause withdrawal symptoms. Your doctor will guide you on how to taper off slowly.
Will pregabalin make me feel drowsy?
Yes, pregabalin can cause dizziness and drowsiness. If you feel any such symptoms, it's better not to drive or do anything that requires alertness.
Comprehensive Drug Guide
How Does Lyrica CR Work?
Pregabalin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action inhibits the release of excitatory neurotransmitters, such as glutamate, norepinephrine, and substance P, which helps to decrease pain signals and improve mood.
What is Lyrica CR Used For?
Common Dosages
- Capsules: 82.5 mg and 165 mg.
Typical Dosing
- The usual recommended starting dose is 165 mg once daily, which may be adjusted based on individual response and tolerability. The maximum recommended dose is 330 mg per day.
Typical Dosing
FDA Approved Indications
- Neuropathic Pain: associated with diabetic peripheral neuropathy and postherpetic neuralgia.
- Fibromyalgia: for the management of fibromyalgia symptoms.
- Generalized Anxiety Disorder: for the treatment of anxiety.
Off-Label Uses
Who Shouldn't Take Lyrica CR?
- Known hypersensitivity to pregabalin or any component of the formulation.
- History of angioedema associated with previous use of pregabalin.
Advice From The Pharmacist
- Take Lyrica CR exactly as prescribed, and do not adjust the dose without consulting your healthcare provider.
- Gradually discontinue use to minimize withdrawal symptoms if stopping the medication.
- Monitor for signs of new or worsening depression, anxiety, or suicidal thoughts.
Side Effects of Lyrica CR
Common Side Effects
- Dizziness
- Drowsiness
- Dry mouth
- Edema (swelling)
- Weight gain
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Signs of angioedema (swelling of the face, lips, throat)
- Risk of misuse and dependence
Risks and Warnings of Lyrica CR
- CNS Effects: Lyrica CR can cause sedation and dizziness; caution is advised when driving or operating machinery.
- Risk of Abuse: Patients with a history of substanceuse disorders should be monitored closely.
- Withdrawal Symptoms: Sudden discontinuation may lead to withdrawal; tapering off is recommended.
Interactions with Lyrica CR
Common Drug Interactions
- CNS Depressants: Use caution when combining with other CNS depressants (e.g., alcohol, benzodiazepines) due to the risk of increased sedation.
- Diuretics: Monitor fluid retention and edema if taking diuretics concurrently.
Alternatives to Lyrica CR
- Other Anticonvulsants: Such as gabapentin for neuropathic pain.
- Antidepressants: Certain antidepressants (e.g., duloxetine) can also be effective for neuropathic pain and anxiety.
- Pain Management Strategies: Physical therapy, cognitive-behavioral therapy, and other non-pharmacologic treatments.
