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Livtencity
Livtencity, the brand name for maribavir, is an antiviral medication used to treat cytomegalovirus (CMV) infections in adults and pediatric patients aged 12 years and older who have undergone hematopoietic stem cell or solid organ transplantation. CMV is a common viral infection that can become severe in individuals with weakened immune systems, particularly transplant recipients. Livtencity works by inhibiting the activity of the CMV enzyme UL97, thereby preventing viral replication and helping to control the infection.
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Frequently Asked Questions
How long does it take for Livtencity to work?
The effect of Livtencity on CMV infections can vary, but patients often see an improvement within several days to weeks of starting treatment. Your healthcare provider will monitor your response to the medication through regular blood tests.
Can I take Livtencity with other antiviral medications?
Livtencity should not be taken with ganciclovir or valganciclovir, as it can reduce their effectiveness. Always consult your doctor before combining Livtencity with other medications.
What should I do if I miss a dose of Livtencity?
If you miss a dose, take it as soon as you remember, unless it is close to your next scheduled dose. In that case, skip the missed dose and take the next dose at the regular time. Do not double up doses.
Can Livtencity cause changes in taste?
Yes, taste disturbances (dysgeusia) are one of the most common side effects of Livtencity. This may include a metallic taste or loss of taste, and it usually resolves after discontinuing the medication.
How long will I need to take Livtencity?
The duration of treatment with Livtencity depends on your condition and response to the medication. Your doctor will determine how long you need to take Livtencity, and regular blood tests will help monitor your progress.
Comprehensive Drug Guide
How Does Livtencity Work?
Livtencity works by inhibiting the activity of the CMV enzyme UL97, which plays a critical role in the replication of the cytomegalovirus. By blocking this enzyme, maribavir prevents the virus from multiplying and spreading in the body, which is particularly important for transplant patients who are at increased risk for severe CMV infections due to their compromised immune systems.
Common Dosages
- 200 mg oral tablets
The typical dosage is 400 mg (two 200 mg tablets) taken twice daily, with or without food.
Typical Dosing
- For post-transplant CMV infection: The usual recommended dose is 400 mg (two 200 mg tablets) twice daily. Treatment duration is typically based on the patient's response and the severity of the CMV infection. Tablets can be taken with or without food.
Typical Dosing
FDA Approved Indications
- The treatment of post-transplant cytomegalovirus (CMV) infection and CMV disease in adults and pediatric patients (aged 12 years and older) who weigh at least 35 kg and are resistant or refractory to conventional antiviral therapies such as ganciclovir, valganciclovir, foscarnet, or cidofovir.
Who Shouldn't Take Livtencity?
- Known hypersensitivity to maribavir or any of the components of Livtencity.
- Use with ganciclovir or valganciclovir is contraindicated, as Livtencity can reduce the effectiveness of these medications.
Advice From The Pharmacist
- Livtencity should be taken twice daily with or without food. Stick to the prescribed schedule to maintain consistent levels of the medication in the body.
- If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not double up doses to make up for the missed one.
- Swallow the tablets whole. Do not crush, chew, or split the tablets.
- Regular blood monitoring may be necessary to track the progress of your CMV infection and ensure the medication is working effectively.
Side Effects of Livtencity
Common Side Effects
- Taste disturbances (dysgeusia), which can range from metallic tastes to taste loss
- Nausea
- Diarrhea
- Fatigue
- Abdominal pain
Uncommon/Severe Side Effects
- Elevation of liver enzymes (indicating potential liver issues)
- Severe allergic reactions, such as rash, itching, swelling, or difficulty breathing
Risks and Warnings of Livtencity
- Taste Disturbances: Dysgeusia (taste changes) is a common side effect of Livtencity. While this is usually mild, some patients may find it unpleasant. Taste disturbances typically resolve after discontinuation of treatment.
- Liver Enzyme Elevation: Livtencity may cause elevations in liver enzymes, so patients should have their liver function monitored during treatment. Contact your healthcare provider if you notice symptoms such as jaundice (yellowing of the skin or eyes), dark urine, or persistent nausea.
- Drug Interactions: Livtencity should not be used with ganciclovir or valganciclovir, as it may reduce their effectiveness.
Interactions with Livtencity
Common Drug Interactions
- Ganciclovir and valganciclovir: These antiviral medications should not be used with Livtencity, as maribavir can decrease their effectiveness.
- Cyclosporine and tacrolimus: These immunosuppressive medications, commonly used in transplant patients, may interact with Livtencity. Dose adjustments may be needed under close supervision by your healthcare provider.
- Antacids: Aluminum or magnesium-containing antacids may reduce the absorption of Livtencity. Take Livtencity at least 2 hours before or after taking antacids.
Alternatives to Livtencity
- Ganciclovir: An antiviral medication used to treat CMV infections, typically as first-line therapy.
- Valganciclovir: A prodrug of ganciclovir, used to treat CMV infections and prevent CMV disease in high-risk patients, such as those who have received an organ transplant.
- Foscarnet: Another antiviral used for CMV infections, particularly in cases where ganciclovir-resistant CMV strains are present.
- Cidofovir: An antiviral used to treat CMV retinitis in immunocompromised patients, including those with AIDS.
