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Levamlodipine Maleate
Levamlodipine maleate is a calcium channel blocker used primarily for the treatment of hypertension (high blood pressure) and angina (chest pain). It is the levo-isomer of amlodipine, providing similar therapeutic effects with potentially fewer side effects.
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Frequently Asked Questions
How long does it take for Levamlodipine Maleate to start working?
Levamlodipine typically begins to lower blood pressure within 2 to 4 hours, with peak effects occurring around 6 to 8 hours after administration.
Can I take Levamlodipine Maleate with other medications?
Always consult your healthcare provider before combining Levamlodipine with other medications, especially those affecting blood pressure.
What should I do if I miss a dose of Levamlodipine Maleate?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Levamlodipine Maleate during pregnancy?
Levamlodipine Maleate should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Levamlodipine Maleate cause weight gain?
Weight gain is not commonly reported with Levamlodipine. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Levamlodipine Maleate Work?
Levamlodipine works by inhibiting calcium ions from entering the smooth muscle and cardiac muscle cells. This action leads to vasodilation (widening of blood vessels), reduced peripheral vascular resistance, and decreased workload on the heart, thereby lowering blood pressure and alleviating angina symptoms.
Common Dosages
- Tablets: Common dosages include 2.5 mg, 5 mg, and 10 mg.
Typical Dosing
- The usual starting dose for adults is 2.5 mg to 5 mg taken orally once daily, which may be adjusted based on blood pressure response and tolerability.
Typical Dosing
FDA Approved Indications
- Management of hypertension.
- Treatment of chronic stable angina.
Who Shouldn't Take Levamlodipine Maleate?
- Known hypersensitivity to levamlodipine or any components of the formulation
- Severe hypotension (low blood pressure)
- Aortic stenosis or other significant heart conditions
Advice From The Pharmacist
- Patients should be advised to take Levamlodipine maleate at the same time each day to maintain consistent blood levels.
- Encourage regular monitoring of blood pressure to assess treatment effectiveness.
- Discuss potential side effects and the importance of lifestyle modifications, including diet and exercise, for managing hypertension.
Side Effects of Levamlodipine Maleate
Common Side Effects
- Swelling of the ankles or feet (peripheral edema)
- Dizziness or lightheadedness
- Fatigue
- Flushing
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Heart rhythm disturbances
- Worsening of angina
Risks and Warnings of Levamlodipine Maleate
- Heart Rate Monitoring: Patients with pre-existing heart conditions should be monitored closely for any changes in heart rate or rhythm.
- Hypotension: Monitor blood pressure regularly, especially after initiating therapy or increasing the dose.
Interactions with Levamlodipine Maleate
Common Drug Interactions
- Other Antihypertensives: Caution is advised when used with other medications that lower blood pressure to avoid excessive hypotension.
- CYP450 Inhibitors: Certain medications may affect the metabolism of levamlodipine and require dosage adjustments.
Alternatives to Levamlodipine Maleate
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for similar indications.
- Other Antihypertensives: Including ACE inhibitors or angiotensin receptor blockers (ARBs) for managing hypertension.
