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Lescol XL
Lescol XL (fluvastatin) is a statin medication used to lower cholesterol levels and reduce the risk of cardiovascular disease. It is particularly effective in reducing low-density lipoprotein (LDL) cholesterol and total cholesterol, helping to improve overall lipid profiles.
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Frequently Asked Questions
How long does it take for Lescol XL to start working?
Lescol XL typically begins to lower cholesterol levels within 1 to 2 weeks, with maximum effects observed after about 4 to 6 weeks of treatment.
Can I take Lescol XL with other medications?
Always consult your healthcare provider before combining Lescol XL with other medications, especially those affecting cholesterol or liver function.
What should I do if I miss a dose of Lescol XL?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Lescol XL during pregnancy?
Lescol XL is contraindicated during pregnancy; women of childbearing age should use effective contraception while on this medication.
Can Lescol XL cause weight gain?
Weight gain is not commonly reported with Lescol XL. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Lescol XL Work?
Fluvastatin works by inhibiting the enzyme HMG-CoA reductase, which is involved in the cholesterol biosynthesis pathway. By blocking this enzyme, fluvastatin decreases cholesterol production in the liver, leading to reduced levels of LDL cholesterol and total cholesterol in the bloodstream.
Common Dosages
- Extended-release tablets: Common dosages include 80 mg.
Typical Dosing
- The usual starting dose is 80 mg taken orally once daily, typically in the evening. Dosages may be adjusted based on lipid levels and patient response.
Typical Dosing
FDA Approved Indications
- Hyperlipidemia: To reduce elevated total cholesterol and LDL cholesterol levels.
- Prevention of cardiovascular events in patients with elevated cholesterol levels and other risk factors.
Who Shouldn't Take Lescol XL?
- Known hypersensitivity to fluvastatin or any components of the formulation
- Active liver disease or unexplained persistent elevations of liver transaminases
- Pregnancy or breastfeeding
Advice From The Pharmacist
- Patients should be advised to take Lescol XL as prescribed and to have regular follow-up appointments to monitor cholesterol levels and liver function.
- Discuss the importance of lifestyle changes, including diet and exercise, as part of cholesterol management.
- Inform patients about potential side effects and encourage them to report any muscle pain or weakness.
Side Effects of Lescol XL
Common Side Effects
- Headache
- Nausea
- Diarrhea
- Abdominal pain
Uncommon/Severe Side Effects
- Myopathy or rhabdomyolysis (muscle breakdown)
- Liver enzyme abnormalities
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Lescol XL
- Muscle Pain: Patients should be monitored for signs of muscle pain or weakness, especially when starting treatment or increasing the dose.
- Liver Function: Regular monitoring of liver enzymes is recommended, particularly in patients with a history of liver disease.
Interactions with Lescol XL
Common Drug Interactions
- Other Lipid-Lowering Agents: Caution is advised when used with other cholesterol-lowering medications to avoid increased risk of muscle-related side effects.
- CYP450 Inhibitors: Certain medications may affect the metabolism of fluvastatin and require dosage adjustments.
Alternatives to Lescol XL
- Other Statins: Such as atorvastatin or simvastatin for similar lipid-lowering effects.
- Non-statin Medications: Such as ezetimibe for cholesterol management.
