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Krintafel
Krintafel (tafenoquine) is a medication designed to combat a nasty parasite that causes malaria. This medication is keen on tackling the form of malaria that remains dormant in the liver and can cause relapses. Note, that it's only used as part of a combination treatment to prevent relapses of Plasmodium vivax malaria, not on its own. Some may experience side effects like dizziness, nausea, or vomiting, but your healthcare provider will weigh these against the potential benefits.
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Frequently Asked Questions
Can I take Krintafel while pregnant?
The safety and efficacy of Krintafel for use during pregnancy haven't been established. Consulting with your healthcare provider is strongly suggested before taking Krintafel if you're pregnant.
How long does Krintafel stay in your system?
The active substance of Krintafel has a long halflife (approximately 15 days), so it may take several weeks to eliminate from your system.
I missed a dose of Krintafel, what should I do?
Since Krintafel is usually given as a onetime dose, this is unlikely. However, if necessary, contact your healthcare provider for instructions.
Comprehensive Drug Guide
How Does Krintafel Work?
Krintafel (tafenoquine) is an 8aminoquinoline derivative that works as an antimalarial, acting against the hepatic stages of Plasmodium vivax parasite.
What is Krintafel Used For?
FDA indications: Krintafel, along with chloroquine, is used in adults and children who weigh at least 25 kg (about 55 lbs), to prevent relapses of Plasmodium vivax malaria.
Offlabel uses: It's not used offlabel. It's a very specialized drug that targets dormant liver stages of Plasmodium vivax.
Common Dosages
Tablets: 100 mg.
Typical Dosing
FDA Approved Indications
- For preventing relapse of Plasmodium vivax malaria: 300mg as a single dose along with chloroquine.
Off-Label Uses
- There's no offlabel use for Krintafel.
Who Shouldn't Take Krintafel?
- If you have a deficiency of an enzyme called G6PD (Glucose6phosphate dehydrogenase), it can cause severe anemia.
- If you are breastfeeding a child who has G6PD deficiency or whose G6PD status is unknown.
- If you have a history of psychotic disorders or current psychotic symptoms
- If you're allergic to Krintafel or any of its components.
Advice From The Pharmacist
- Consider getting a G6PD test. People who lack the enzyme G6PD could develop anemia from Krintafel.
- You may have to take a pregnancy test to ensure you're not pregnant before starting this therapy (it's not safe for use during pregnancy).
- If the medication gives you issues like vomiting or dizziness, reach out to your healthcare provider for advice.
- Remember to follow your healthcare provider's instructions and take Krintafel combination therapy as prescribed.
Side Effects of Krintafel
Common Side Effects
- It can make you feel dizzy or disoriented.
- You might feel sick to your stomach or even vomit.
- You might have a headache or have trouble sleeping.
Uncommon/Severe Side Effects
- Uncommon side effects:
- You might notice changes in your heart rate or rhythm.
- You might experience muscle weakness or pain.
- Rare side effects:
- You might have symptoms of methemoglobinemia (a blood disorder), like the bluish color of the lips or nail beds, headache, fatigue, shortness of breath, etc.
- You might experience vision changes.
- Severe side effects:
- If you notice dark urine or yellowing of the skin or eyes, seek immediate medical help.
- If you see any signs of severe mental health issues like psychosis or suicidal ideation, get immediate medical attention.
Risks and Warnings of Krintafel
- The safety and efficacy of Krintafel for use during pregnancy haven't been established, avoid it if possible.
- If you're G6PD deficient, Krintafel can cause severe hemolysis (breaking down of red blood cells), leading to anemia.
- The drug can cause psychiatric adverse effects like restlessness, anxiety, depression, and suicidal ideation. Avoid it if you have a history of psychiatric illness.
- If you're breastfeeding a child who's G6PD deficient, it's also not safe to take Krintafel.
- This medicine is not effective against all malaria forms and species. It should not be used for treatment of acute malaria.
Interactions with Krintafel
Common Drug Interactions
- Chloroquine
- Primaquine
Alternatives to Krintafel
- Primaquine
- Hydroxychloroquine
- Atovaquone/proguanil
- Mefloquine
