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Klisyri
Klisyri (tirbanibulin) is a topical medication used for the treatment of actinic keratosis, a condition characterized by rough, scaly patches on the skin caused by sun damage. It is designed to help remove these lesions by promoting local skin cell turnover and improving skin appearance.
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Frequently Asked Questions
How long does it take for Klisyri to start working?
Patients may begin to notice improvements in the appearance of actinic keratosis lesions within 2 to 4 weeks after completing the treatment course.
Can I take Klisyri with other medications?
Always consult your healthcare provider before combining Klisyri with other topical medications to avoid increased irritation.
What should I do if I miss a dose of Klisyri?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled application, skip the missed dose and continue with your regular schedule.
Is it safe to use Klisyri during pregnancy?
Klisyri should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Klisyri cause weight gain?
Weight gain is not associated with Klisyri. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Klisyri Work?
Tirbanibulin works by inhibiting the enzyme tubulin, which is essential for cell division and proliferation. By disrupting the normal function of tubulin, Klisyri promotes the death of abnormal skin cells associated with actinic keratosis, leading to the resolution of lesions.
Common Dosages
- Topical ointment: Available as 1% tirbanibulin.
Typical Dosing
- The usual dosage is to apply a thin layer of Klisyri to the affected area once daily for 5 consecutive days. Treatment can be repeated if necessary, based on clinical evaluation.
Typical Dosing
FDA Approved Indications
- Topical treatment of actinic keratosis on the face or scalp
Who Shouldn't Take Klisyri?
- Known hypersensitivity to tirbanibulin or any components of the formulation
- Active skin infections at the treatment site
Advice From The Pharmacist
- Patients should be advised to apply Klisyri exactly as directed and to avoid occluding the treated area with bandages or clothing.
- Encourage patients to wash their hands before and after application to avoid accidental transfer to other areas.
- Discuss the importance of sun protection during and after treatment, as skin may be more sensitive to sunlight.
Side Effects of Klisyri
Common Side Effects
- Application site reactions (redness, itching, burning)
- Dry skin
- Erosion or ulceration of the skin
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Infection at the application site
Risks and Warnings of Klisyri
- Local Irritation: Monitor for excessive irritation or allergic reactions at the application site.
- Sun Sensitivity: Advise patients to use sunscreen and protective clothing during treatment to minimize sun exposure.
Interactions with Klisyri
Common Drug Interactions
- Other Topical Medications: Caution should be used when applying Klisyri in conjunction with other topical treatments to avoid increased irritation.
Alternatives to Klisyri
- Other Topical Treatments: Such as imiquimod or fluorouracil for actinic keratosis.
- Cryotherapy: Liquid nitrogen treatment for localized lesions.
