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Keveyis
Keveyis (dichlorphenamide) is a medication used to treat primary hyperkalemic periodic paralysis and related conditions. It helps to reduce the frequency of attacks and manage symptoms associated with these disorders by acting on muscle excitability.
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Frequently Asked Questions
How long does it take for Keveyis to start working?
Patients may begin to notice a reduction in the frequency of attacks within a few weeks of starting treatment.
Can I take Keveyis with other medications?
Always consult your healthcare provider before combining Keveyis with other medications, particularly those affecting potassium levels.
What should I do if I miss a dose of Keveyis?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Keveyis during pregnancy?
Keveyis should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Keveyis cause weight gain?
Weight gain is not commonly associated with Keveyis. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Keveyis Work?
Dichlorphenamide works by inhibiting the enzyme carbonic anhydrase, which leads to increased renal excretion of bicarbonate and enhanced retention of potassium. This action helps to stabilize muscle membranes and reduce excitability, thus decreasing the frequency of muscle paralysis attacks.
Common Dosages
Typical Dosing
- The usual starting dose is 50 mg taken orally once daily, which may be adjusted based on clinical response and tolerability. Doses can be increased gradually, up to a maximum of 200 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of primary hyperkalemic periodic paralysis and related conditions.
Who Shouldn't Take Keveyis?
- Known hypersensitivity to dichlorphenamide or any components of the formulation
- Severe kidney or liver disease
- Adrenal insufficiency
Advice From The Pharmacist
- Patients should be advised to take Keveyis exactly as prescribed, with or without food.
- Discuss the importance of staying hydrated and monitoring for signs of electrolyte imbalances.
- Encourage patients to report any unusual symptoms or side effects, particularly those related to muscle function.
Side Effects of Keveyis
Common Side Effects
- Nausea
- Diarrhea
- Fatigue
- Dizziness
- Paresthesia (tingling sensation)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Electrolyte imbalances (e.g., hypokalemia)
- Metabolic acidosis
Risks and Warnings of Keveyis
- Electrolyte Monitoring: Regular monitoring of potassium levels and overall electrolytes is important during treatment.
- Kidney Function: Assess renal function periodically, especially in patients with pre-existing kidney conditions.
Interactions with Keveyis
Common Drug Interactions
- Diuretics: Caution is advised when combining with potassium-sparing diuretics due to the risk of hyperkalemia.
- Other Carbonic Anhydrase Inhibitors: Concurrent use may increase the risk of side effects.
Common Food Interactions
Alternatives to Keveyis
- Other Treatments for Periodic Paralysis: Such as acetazolamide or other carbonic anhydrase inhibitors for managing symptoms.
- Lifestyle Modifications: Dietary changes or lifestyle adjustments to manage symptoms effectively.
