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Dichlorphenamide

Dichlorphenamide is a type of medication called a carbonic anhydrase inhibitor. It is used to treat a rare genetic disorder called periodic paralysis, where the patient suffers from occasional episodes of muscle weakness or paralysis. The common side effects can include a loss of appetite, a metallic taste in the mouth, and feeling tired. Your healthcare provider will weigh the benefits against these potential issues.

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Frequently Asked Questions

Can I drink alcohol while taking Dichlorphenamide?
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It's best to avoid alcohol while on dichlorphenamide as it can worsen certain side effects such as dizziness and confusion.

I feel dizzy or drowsy after taking Dichlorphenamide, is that normal?
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Yes, dizziness and drowsiness are common side effects. If these symptoms persist or worsen, consult your doctor.

What should I do if I miss a dose of Dichlorphenamide?
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If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Comprehensive Drug Guide

How Does Dichlorphenamide Work?

Dichlorphenamide is a carbonic anhydrase inhibitor. It works by decreasing the buildup of body fluids (edema) caused by congestive heart failure or certain medications. It could also decrease a third space accumulation of body fluids due to primary kidney disease.

What is Dichlorphenamide Used For?

FDA indications: Dichlorphenamide is primarily used to treat periodic paralysis, which causes occasional episodes of extreme muscle weakness or not being able to move at all.

Offlabel uses: There are no known offlabel uses

Common Dosages

Tablets: 50mg

Typical Dosing

FDA Approved Indications

  • Primary periodic paralysis: The initial recommended dosage is 50 mg twice daily. Dosage can be adjusted based on the individual patient's response to therapy.

Who Shouldn't Take Dichlorphenamide?

  • Those who have severe kidney disease, liver disease, or certain types of eye problems (high level of Chloride in Cornea and Lens).
  • Those with low levels of potassium (hypokalemia) or sodium (hyponatremia) in the blood.
  • Those who are allergic to dichlorphenamide or other sulfonamides.
  • Those who have adrenal gland problems (e.g., Addision's disease).
  • Pregnant or planning to get pregnant, as the effects of dichlorphenamide on pregnancy are unknown.

Advice From The Pharmacist

  • Take this medication with food if it upsets your stomach.
  • Drink enough liquids while on this medication unless instructed to do otherwise.
  • It is advised to avoid activities requiring mental clarity such as driving, until your body adjusts to the medication.
  • This medicine could cause dizziness or vision problems. It can also increase your risk of falling.
  • Do not stop taking dichlorphenamide suddenly without talking to your doctor.
  • Regular checkups are necessary for monitoring progress and potential side effects.

Side Effects of Dichlorphenamide

Common Side Effects

  • Loss of appetite
  • Nausea
  • Vomiting
  • Feeling tired

Uncommon/Severe Side Effects

  • Uncommon side effects:
  • Decreased sensation to touch
  • Discomfort in the chest
  • Rare side effects:
  • You might have muscle cramps or spasms
  • Confusion
  • Dizziness
  • Severe side effects:
  • Fast or irregular heartbeat
  • Shortness of breath
  • Swelling of feet or lower legs
  • Unusual tiredness or weakness

Risks and Warnings of Dichlorphenamide

  • May cause serious allergic reactions including anaphylaxis and severe rash.
  • Blood disorders have been reported in patients treated with carbonic anhydrase inhibitors.
  • May cause serious side effects like changes in the level of red or white blood cells.
  • Should use caution in patients with a history of kidney stones.
  • It may also make your skin sensitive to sunlight.
  • Interactions

Interactions with Dichlorphenamide

Common Drug Interactions

  • High doses of aspirin
  • Corticosteroids
  • Primidone

Alternatives to Dichlorphenamide

  • Acetazolamide
  • Methazolamide