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Keppra XR
Keppra XR (levetiracetam) is an anticonvulsant medication used primarily for the treatment of epilepsy. It is indicated for the management of partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures in adults and children. The extended-release formulation allows for convenient once-daily dosing, improving patient compliance.
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Frequently Asked Questions
How long does it take for Keppra XR to start working?
Patients may begin to notice a reduction in seizure frequency within a few weeks, but optimal effects may take longer to establish.
Can I take Keppra XR with other medications?
Always consult your healthcare provider before combining Keppra XR with other medications, especially other antiepileptic drugs or CNS depressants.
What should I do if I miss a dose of Keppra XR?
If you miss a dose, take it as soon as you remember on the same day. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Keppra XR during pregnancy?
Keppra XR should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Keppra XR cause weight gain?
Weight gain is not a common side effect of Keppra XR; however, any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Keppra XR Work?
Levetiracetam works by modulating neurotransmitter release through binding to the synaptic vesicle protein SV2A, which is thought to inhibit the release of excitatory neurotransmitters. This action helps stabilize neuronal activity and reduce the frequency of seizures.
What is Keppra XR Used For?
Common Dosages
- Extended-release tablets: Common dosages include 500 mg, 750 mg, and 1000 mg.
Typical Dosing
- The usual starting dose for adults is 500 mg taken once daily. The dose may be increased based on individual response, with a maximum dose of 3000 mg per day.
Typical Dosing
FDA Approved Indications
- Treatment of partial-onset seizures in adults and children aged 4 years and older.
- Treatment of myoclonic seizures in patients aged 12 years and older with juvenile myoclonic epilepsy.
- Treatment of generalized tonic-clonic seizures in adults and children aged 6 years and older.
Off-Label Uses
- Known hypersensitivity to levetiracetam or any components of the formulation.
Who Shouldn't Take Keppra XR?
- Known hypersensitivity to levetiracetam or any components of the formulation.
Advice From The Pharmacist
- Patients should be advised to take Keppra XR at the same time each day to maintain consistent blood levels.
- Encourage adherence to the prescribed dosing schedule and caution against abrupt discontinuation, as this may increase seizure risk.
- Advise patients to report any unusual mood changes, including depression or anxiety.
Side Effects of Keppra XR
Common Side Effects
- Drowsiness
- Fatigue
- Dizziness
- Headache
- Irritability
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Changes in mood or behavior, including suicidal thoughts
- Blood disorders (e.g., thrombocytopenia)
Risks and Warnings of Keppra XR
- Psychiatric Effects: Monitor for mood changes, depression, or suicidal thoughts, particularly during the initiation of treatment or dose changes.
- Renal Impairment: Dose adjustments may be necessary in patients with impaired renal function.
Interactions with Keppra XR
Common Drug Interactions
- Other Antiepileptic Drugs: May require monitoring for additive effects or interactions.
- CNS Depressants: Caution is advised when using with other medications that may cause sedation or respiratory depression.
Alternatives to Keppra XR
- Other Antiepileptic Medications: Such as lamotrigine, carbamazepine, or levetiracetam (immediate-release) for similar indications.
- Non-Pharmacologic Treatments: Such as dietary therapies (e.g., ketogenic diet) or neuromodulation techniques.
