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Karbinal ER

Karbinal ER (carbinoxamine maleate) is an antihistamine medication used primarily to relieve symptoms associated with allergic rhinitis (hay fever), including sneezing, runny nose, and itching. The extended-release formulation allows for convenient once-daily dosing, providing sustained symptom relief.

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Frequently Asked Questions

How long does it take for Karbinal ER to start working?
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Karbinal ER typically begins to relieve allergy symptoms within 1 to 2 hours after administration.

Can I take Karbinal ER with other medications?
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Always consult your healthcare provider before combining Karbinal ER with other medications, especially other antihistamines or CNS depressants.

What should I do if I miss a dose of Karbinal ER?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is it safe to use Karbinal ER during pregnancy?
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Karbinal ER should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Karbinal ER cause weight gain?
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Weight gain is not a common side effect of Karbinal ER. Any significant changes in weight should be discussed with a healthcare provider.

Comprehensive Drug Guide

How Does Karbinal ER Work?

Carbinoxamine works by blocking the action of histamine at the H1 receptor sites. This action reduces the symptoms of allergic reactions, including itching, sneezing, and nasal congestion. As a first-generation antihistamine, it may also have sedative effects.



Common Dosages

  • Extended-release tablets: Commonly available in 8 mg or 12 mg strengths.

Typical Dosing

  • The usual dosage is 1 extended-release tablet taken orally once daily, preferably in the evening, to minimize sedation.


Typical Dosing

FDA Approved Indications

  • Relief of symptoms associated with allergic rhinitis.
  • Management of symptoms of other allergic conditions, such as allergic conjunctivitis.


Who Shouldn't Take Karbinal ER?

  • Known hypersensitivity to carbinoxamine or any components of the formulation
  • Severe asthma or other lower respiratory conditions
  • Glaucoma
  • Prostatic hypertrophy


Advice From The Pharmacist

  • Patients should be advised to take Karbinal ER at the same time each day for maximum effectiveness.
  • Inform patients about the potential for sedation and advise them to avoid activities that require alertness, such as driving, until they know how the medication affects them.
  • Encourage patients to stay hydrated and consult a healthcare provider if symptoms persist or worsen.


Side Effects of Karbinal ER

Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Fatigue
  • Nausea


Uncommon/Severe Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Increased intraocular pressure
  • Urinary retention


Risks and Warnings of Karbinal ER

  • CNS Depression: Caution is advised in patients with a history of alcohol or drug abuse, as Karbinal ER can enhance sedation.
  • Anticholinergic Effects: Patients with conditions exacerbated by anticholinergic effects (e.g., glaucoma, urinary retention) should use caution.


Interactions with Karbinal ER

Common Drug Interactions

  • CNS Depressants: Use caution when taking Karbinal ER with other medications that may cause sedation or respiratory depression.
  • Other Antihistamines: Avoid combining with other antihistamines to prevent additive effects.


Alternatives to Karbinal ER

  • Other Antihistamines: Such as cetirizine or loratadine for similar allergic symptoms.
  • Intranasal Steroids: For persistent allergic rhinitis and nasal congestion.