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Isosorb Dinitrate-hydrALAZINE
Isosorb Dinitrate-Hydralazine is a combination medication that includes isosorbide dinitrate, a nitrate, and hydralazine, a vasodilator. This combination is primarily used for the management of heart failure and hypertension, helping to reduce the workload on the heart and improve blood flow.
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Frequently Asked Questions
How long does it take for Isosorb Dinitrate-Hydralazine to start working?
Patients may begin to notice improvements in symptoms within 30 minutes to 1 hour after administration, but it may take longer for optimal effects in managing heart failure.
Can I take Isosorb Dinitrate-Hydralazine with other medications?
Always consult your healthcare provider before combining Isosorb Dinitrate-Hydralazine with other medications, especially those that lower blood pressure.
What should I do if I miss a dose of Isosorb Dinitrate-Hydralazine?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Isosorb Dinitrate-Hydralazine during pregnancy?
Isosorb Dinitrate-Hydralazine should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Isosorb Dinitrate-Hydralazine cause weight gain?
Weight gain is not a common side effect of Isosorb Dinitrate-Hydralazine. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Isosorb Dinitrate-hydrALAZINE Work?
- Isosorbide Dinitrate: Works by dilating blood vessels, which decreases the amount of blood returning to the heart (preload), thereby reducing the heart's workload and oxygen demand.
- Hydralazine: Directly relaxes the smooth muscles of blood vessels, leading to vasodilation and decreased systemic vascular resistance.
Common Dosages
- Tablets: Common dosages may include 20 mg isosorbide dinitrate and 37.5 mg hydralazine.
Typical Dosing
- The usual dosage is one tablet taken orally three times daily, with adjustments made based on individual response and tolerability.
Typical Dosing
FDA Approved Indications
- Management of heart failure
- Treatment of hypertension
Who Shouldn't Take Isosorb Dinitrate-hydrALAZINE?
- Known hypersensitivity to isosorbide dinitrate, hydralazine, or any components of the formulation
- Severe aortic stenosis
- Hypotension (low blood pressure)
- History of systemic lupus erythematosus (SLE) when using hydralazine
Advice From The Pharmacist
- Patients should be advised to take Isosorb Dinitrate-Hydralazine with food to minimize gastrointestinal irritation.
- Encourage patients to monitor their blood pressure regularly and report any significant changes or side effects.
- Inform patients about the possibility of dizziness, especially when standing up quickly, and advise them to rise slowly.
Side Effects of Isosorb Dinitrate-hydrALAZINE
Common Side Effects
- Headache
- Dizziness
- Nausea
- Flushing
- Palpitations
Uncommon/Severe Side Effects
- Severe hypotension (low blood pressure)
- Tachycardia (rapid heartbeat)
- Allergic reactions (anaphylaxis)
Risks and Warnings of Isosorb Dinitrate-hydrALAZINE
- Cardiovascular Risks: Monitor patients closely, particularly those with pre-existing heart conditions, as the combination can significantly lower blood pressure.
- Monitoring: Regular follow-up appointments are essential to assess effectiveness and any potential side effects.
Interactions with Isosorb Dinitrate-hydrALAZINE
Common Drug Interactions
- Other Antihypertensives: Caution is advised when using with other medications that lower blood pressure, as this may increase the risk of hypotension.
- Ethanol: Alcohol can enhance the hypotensive effects of Isosorb Dinitrate-Hydralazine, and patients should be advised to limit alcohol intake.
Alternatives to Isosorb Dinitrate-hydrALAZINE
- Other Heart Failure Medications: Such as ACE inhibitors or beta-blockers for managing heart failure.
- Other Antihypertensive Agents: For hypertension, alternative options may include diuretics or calcium channel blockers.