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Hydralazine HCL
Hydralazine is a type of drug that falls under the category of vasodilators. It is mainly used to treat high blood pressure (hypertension) as it helps to relax and widen the blood vessels allowing blood to flow more easily.
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Frequently Asked Questions
Does hydralazine affect heart rate?
Before you start taking this medication, you should talk to your doctor about your liver health. They may need to adjust your dose or consider other treatment options.
I missed a dose of hydralazine, what should I do?
Yes, hydralazine can cause a rapid heart rate. If you have heart conditions, you should discuss this with your doctor.
Can I stop taking hydralazine all of a sudden?
If it is near the time for your next dose, skip the missed dose and take your next dose at your usual time. But if it is not, take the missed dose as soon as you remember.
Will hydralazine affect my pregnancy?
No, this could cause a rapid increase in blood pressure. Always follow your doctor's instructions about tapering the dose.
Comprehensive Drug Guide
How Does Hydralazine HCL Work?
Hydralazine causes direct arterial smooth muscle relaxation leading to a decrease in peripheral vascular resistance and subsequent reduction in blood pressure.
What is Hydralazine HCL Used For?
FDA indications: Hydralazine is used to treat high blood pressure and heart failure.
Off-label uses: It can also be used to treat congestive heart failure and eclampsia during pregnancy.
Common Dosages
Hydralazine is commonly manufactured in tablet formulations of 10mg, 25mg, 50mg, 100mg
Typical Dosing
FDA Approved Indications
- Hypertension: 10 to 50mg four times a day.
- Heart Failure: 25 to 50mg three to four times a day.
Off-Label Uses
- Hypertensive emergency and eclampsia: Dosing varies and is hospital-based.
Who Shouldn't Take Hydralazine HCL?
- Coronary Artery Disease: Hydralazine may induce reflex tachycardia, potentially exacerbating myocardial ischemia in patients with coronary artery disease.
- Mitral Valvular Rheumatic Heart Disease: Hydralazine can decrease afterload, but may exacerbate symptoms if pulmonary edema is present due to increased mitral valve regurgitation.
- Renal or Liver Disease: The metabolism and excretion of hydralazine may be altered, leading to increased drug levels and potential toxicity in patients with impaired renal or liver function.
Advice From The Pharmacist
- Try to stand up slowly and avoid sudden position changes. This can prevent dizziness or fainting spells due to low blood pressure.
- Watch over your heart. If you feel an irregular heartbeat, chest pain, or other heart-related symptoms, make sure to consult your doctor.
- Let your doctor know about any numbness, tingling, or pain in your hands or feet, as this could be a sign of nerve damage.
- For women planning to become pregnant or are pregnant, make sure to ask your doctor about the use of hydralazine.
- Lastly, always follow up with your doctor, get regular blood pressure checks, and keep living a heart-healthy lifestyle (balanced diet, physical activity, no smoking, limited alcohol, etc).
Side Effects of Hydralazine HCL
Common Side Effects
- Headaches
- Upset stomach
- Fast heart rate
- Sweating.
Uncommon/Severe Side Effects
- Very rarely, people may experience more serious side effects such as an irregular heartbeat, chest pain, or shortness of breath. If you experience any of these side effects, it's important to seek medical attention right away.
Risks and Warnings of Hydralazine HCL
- Hydralazine may cause a drop in blood pressure, which can lead to dizziness or fainting. Make sure to monitor your blood pressure levels regularly.
- If you've been diagnosed with kidney or liver problems, Lupus, or angina, be sure to inform your doctor, as Hydralazine may not be suitable for you.
- Hydralazine does pass into breast milk, so caution should be exercised if you're breastfeeding. Discuss with your healthcare provider to understand the potential risks and benefits.
Interactions with Hydralazine HCL
Common Drug Interactions
- Furosemide
- Beta-blockers
- NSAIDs
- Other high blood pressure medications
Alternatives to Hydralazine HCL
- Lisinopril
- Amlodipine
- Losartan
- Metoprolol
- Enalapril
