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Invega Trinza
Invega Trinza (paliperidone palmitate) is an atypical antipsychotic medication used for the treatment of schizophrenia in adults. It is a long-acting injectable formulation that provides sustained medication delivery over an extended period, typically administered every three months. Invega Trinza helps to stabilize mood, reduce the risk of relapse, and improve overall functioning in individuals with schizophrenia.
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Frequently Asked Questions
How long does it take for Invega Trinza to start working?
Patients may begin to notice improvements in symptoms within a few weeks, but it may take several months for full therapeutic effects to be realized.
Can I take Invega Trinza with other medications?
Always consult your healthcare provider before combining Invega Trinza with other medications, especially those affecting the central nervous system.
What should I do if I miss a dose of Invega Trinza?
If a dose is missed, contact your healthcare provider for guidance on when to reschedule the injection.
Is it safe to use Invega Trinza during pregnancy?
Invega Trinza should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider
Can Invega Trinza cause weight gain?
Weight gain is a common side effect of Invega Trinza. Patients should monitor their weight and discuss any significant changes with their healthcare provider.
Comprehensive Drug Guide
How Does Invega Trinza Work?
Invega Trinza works by modulating the effects of various neurotransmitters in the brain, particularly dopamine and serotonin. By antagonizing dopamine D2 receptors and serotonin 5-HT2A receptors, it helps to reduce psychotic symptoms and stabilize mood.
Common Dosages
- Intramuscular injection: Common dosages include 175 mg, 263 mg, and 351 mg per injection.
Typical Dosing
- The recommended dosing schedule is every three months. The initial dose is typically given after completing a treatment with Invega Sustenna (paliperidone palmitate monthly injection) for a minimum of 4 months to ensure adequate plasma levels.
- The specific dosage is individualized based on the patient's needs and previous response to treatment.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults.
Who Shouldn't Take Invega Trinza?
- Known hypersensitivity to paliperidone, risperidone, or any components of the formulation
- Severe renal impairment
Advice From The Pharmacist
- Patients should be educated about the injection technique and the importance of adhering to the scheduled dosing to maintain therapeutic levels.
- Monitor for side effects, especially during the initial treatment phase, and report any concerning symptoms to a healthcare provider.
- It’s important for patients to engage in regular follow-up appointments for monitoring effectiveness and any potential side effects.
Side Effects of Invega Trinza
Common Side Effects
- Weight gain
- Sedation
- Dizziness
- Headache
- Fatigue
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (e.g., tremors, rigidity)
- Tardive dyskinesia (involuntary movements)
- Neuroleptic malignant syndrome (NMS)
Risks and Warnings of Invega Trinza
- Metabolic Changes: Monitor for changes in weight, blood sugar, and lipid levels, as atypical antipsychotics can increase the risk of metabolic syndrome.
- Cardiovascular Risks: Assess cardiovascular health, especially in patients with pre-existing conditions, as there may be an increased risk of stroke and cardiovascular events.
- Elderly Patients: Use with caution in elderly patients with dementia-related psychosis, as there is an increased risk of death.
Interactions with Invega Trinza
Common Drug Interactions
- CNS Depressants: Caution is advised when combining Invega Trinza with other medications that cause sedation or respiratory depression.
- Medications that affect CYP450 enzymes: Invega Trinza is primarily metabolized by CYP2D6; co-administration with inhibitors or inducers may affect plasma levels.
Alternatives to Invega Trinza
- Invega Sustenna: A monthly injectable formulation of paliperidone.
- Risperidone: Another atypical antipsychotic that may be used for schizophrenia.
- Olanzapine: An atypical antipsychotic with a different side effect profile.
