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Invega

Invega (paliperidone) is an atypical antipsychotic medication used to treat schizophrenia and schizoaffective disorder in adults and adolescents. It helps manage symptoms such as hallucinations, delusions, and mood disturbances, promoting overall stability and functionality. Invega is available in both oral and long-acting injectable formulations.



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Frequently Asked Questions

How long does it take for Invega to start working?
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Patients may begin to notice improvements in symptoms within a few weeks, but it may take several months for full therapeutic effects to be realized.

Can I take Invega with other medications?
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Always consult your healthcare provider before combining Invega with other medications, especially those affecting the central nervous system.

What should I do if I miss a dose of Invega?
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If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is it safe to use Invega during pregnancy?
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Invega should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Is it safe to use Invega during pregnancy?
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Invega should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Invega cause weight gain?
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Weight gain is a common side effect of Invega. Patients should monitor their weight and discuss any significant changes with their healthcare provider.

Can Invega cause weight gain?
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Weight gain is a common side effect of Invega. Patients should monitor their weight and discuss any significant changes with their healthcare provider.

Comprehensive Drug Guide

How Does Invega Work?

Invega works by modulating the effects of various neurotransmitters in the brain, particularly dopamine and serotonin. By antagonizing dopamine D2 receptors and serotonin 5-HT2A receptors, it helps reduce psychotic symptoms and stabilize mood.



Common Dosages

  • Oral tablets: Common dosages include 1.5 mg, 3 mg, 6 mg, 9 mg, and 12 mg.
  • Injectable formulations: Available as Invega Sustenna and Invega Hafyera for long-acting administration.

Typical Dosing

  • For schizophrenia: The initial dose is typically 6 mg once daily, which may be adjusted based on clinical response, with a maximum dose of 12 mg per day.
  • For schizoaffective disorder: Dosing is similar, with adjustments made based on individual response.


Typical Dosing

FDA Approved Indications

  • Treatment of schizophrenia in adults and adolescents aged 12 years and older.
  • Treatment of schizoaffective disorder.

Who Shouldn't Take Invega?

  • Known hypersensitivity to paliperidone or any components of the formulation
  • Severe renal impairment


Advice From The Pharmacist

  • Patients should be educated about the importance of adherence to the prescribed treatment regimen to prevent relapse.
  • Regular follow-up appointments are necessary for monitoring efficacy and potential side effects.
  • Patients should be informed about the possibility of sedation and should avoid activities requiring alertness until they know how Invega affects them.


Side Effects of Invega

Common Side Effects

  • Weight gain
  • Drowsiness
  • Dizziness
  • Fatigue
  • Headache


Uncommon/Severe Side Effects

  • Extrapyramidal symptoms (e.g., tremors, rigidity)
  • Tardive dyskinesia (involuntary movements)
  • Neuroleptic malignant syndrome (NMS)


Risks and Warnings of Invega

  • Metabolic Changes: Monitor for weight gain, blood sugar, and lipid levels, as atypical antipsychotics can increase the risk of metabolic syndrome.
  • Cardiovascular Risks: Assess cardiovascular health, especially in patients with pre-existing conditions, as there may be an increased risk of stroke and cardiovascular events.
  • Elderly Patients: Use with caution in elderly patients with dementia-related psychosis, as there is an increased risk of death.


Interactions with Invega

Common Drug Interactions

  • CNS Depressants: Caution is advised when combining Invega with other medications that cause sedation or respiratory depression.
  • Medications that affect CYP450 enzymes: Invega is primarily metabolized by CYP2D6; co-administration with inhibitors or inducers may affect plasma levels.


Alternatives to Invega

  • Invega Sustenna: A monthly injectable formulation for schizophrenia management.
  • Risperidone: Another atypical antipsychotic that may be used for schizophrenia.
  • Olanzapine: An atypical antipsychotic with a different side effect profile.