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Invega Sustenna
Invega Sustenna (paliperidone palmitate) is an atypical antipsychotic medication used for the treatment of schizophrenia in adults and adolescents aged 12 years and older. It is designed as a long-acting injectable formulation that provides a steady release of medication over time, typically administered once a month. This helps improve medication adherence and reduces the risk of relapse in individuals with schizophrenia.
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Frequently Asked Questions
How long does it take for Invega Sustenna to start working?
Patients may begin to notice improvements in symptoms within a few weeks, but it may take several months for full therapeutic effects to be realized.
Can I take Invega Sustenna with other medications?
Always consult your healthcare provider before combining Invega Sustenna with other medications, especially those affecting the central nervous system.
What should I do if I miss a dose of Invega Sustenna?
If a dose is missed, contact your healthcare provider for guidance on when to reschedule the injection.
Is it safe to use Invega Sustenna during pregnancy?
Invega Sustenna should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Is it safe to use Invega Sustenna during pregnancy?
Invega Sustenna should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Invega Sustenna cause weight gain?
Weight gain is a common side effect of Invega Sustenna. Patients should monitor their weight and discuss any significant changes with their healthcare provider.
Comprehensive Drug Guide
How Does Invega Sustenna Work?
Invega Sustenna works by modulating the effects of neurotransmitters in the brain, particularly dopamine and serotonin. By antagonizing dopamine D2 receptors and serotonin 5-HT2A receptors, it helps reduce psychotic symptoms, stabilize mood, and improve overall functioning.
Common Dosages
- Intramuscular injection: Available in doses of 39 mg, 117 mg, 156 mg, and 234 mg.
Typical Dosing
- The initial dose for adults is typically 234 mg administered as a single injection, followed by 117 mg one week later. Maintenance doses of 39 mg to 234 mg are administered once monthly thereafter, based on individual patient response.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults and adolescents aged 12 years and older.
Who Shouldn't Take Invega Sustenna?
- Known hypersensitivity to paliperidone, risperidone, or any components of the formulation
- Severe renal impairment
Advice From The Pharmacist
- Patients should be educated about the injection technique and the importance of adhering to the monthly dosing schedule to maintain therapeutic levels.
- Regular follow-up appointments are necessary for monitoring effectiveness and any potential side effects.
- Patients should be informed about the possibility of sedation and should avoid activities requiring alertness until they know how Invega Sustenna affects them.
Side Effects of Invega Sustenna
Common Side Effects
- Weight gain
- Drowsiness
- Dizziness
- Fatigue
- Headache
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (e.g., tremors, rigidity)
- Tardive dyskinesia (involuntary movements)
- Neuroleptic malignant syndrome (NMS)
Risks and Warnings of Invega Sustenna
- Metabolic Changes: Monitor for weight gain, blood sugar, and lipid levels, as atypical antipsychotics can increase the risk of metabolic syndrome.
- Cardiovascular Risks: Assess cardiovascular health, especially in patients with pre-existing conditions, as there may be an increased risk of stroke and cardiovascular events.
- Elderly Patients: Use with caution in elderly patients with dementia-related psychosis, as there is an increased risk of death.
Interactions with Invega Sustenna
Common Drug Interactions
- Metabolic Changes: Monitor for weight gain, blood sugar, and lipid levels, as atypical antipsychotics can increase the risk of metabolic syndrome.
- Cardiovascular Risks: Assess cardiovascular health, especially in patients with pre-existing conditions, as there may be an increased risk of stroke and cardiovascular events.
- Elderly Patients: Use with caution in elderly patients with dementia-related psychosis, as there is an increased risk of death.
Alternatives to Invega Sustenna
- Invega Trinza: A long-acting formulation given every three months.
- Risperidone: Another atypical antipsychotic that may be used for schizophrenia.
- Olanzapine: An atypical antipsychotic with a different side effect profile.
