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Invega Hafyera

Invega Hafyera (paliperidone palmitate) is an atypical antipsychotic medication used for the treatment of schizophrenia in adults. It is a long-acting injectable formulation designed to provide sustained medication delivery over an extended period, typically administered every six months. This helps improve adherence to treatment and reduces the risk of relapse in individuals with schizophrenia.



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Frequently Asked Questions

How long does it take for Invega Hafyera to start working?
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Patients may begin to notice improvements in symptoms within a few weeks, but it may take several months for full therapeutic effects to be realized.

Can I take Invega Hafyera with other medications?
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Always consult your healthcare provider before combining Invega Hafyera with other medications, especially those affecting the central nervous system.

What should I do if I miss a dose of Invega Hafyera?
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If a dose is missed, contact your healthcare provider for guidance on when to reschedule the injection.

Is it safe to use Invega Hafyera during pregnancy?
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Invega Hafyera should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Invega Hafyera cause weight gain?
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Weight gain is a common side effect of Invega Hafyera. Patients should monitor their weight and discuss any significant changes with their healthcare provider.

Comprehensive Drug Guide

How Does Invega Hafyera Work?

Invega Hafyera works by modulating the effects of neurotransmitters in the brain, particularly dopamine and serotonin. By antagonizing dopamine D2 receptors and serotonin 5-HT2A receptors, it helps reduce psychotic symptoms, stabilize mood, and improve overall functioning.



Common Dosages

  • Intramuscular injection: Available in doses of 1,134 mg.

Typical Dosing

  • The recommended dosing schedule is once every six months after the initial treatment with Invega Sustenna (paliperidone palmitate monthly injection) to ensure adequate plasma levels.
  • The specific dosage is individualized based on the patient's needs and previous response to treatment.


Typical Dosing

FDA Approved Indications

  • Treatment of schizophrenia in adults.


Who Shouldn't Take Invega Hafyera?

  • Known hypersensitivity to paliperidone, risperidone, or any components of the formulation
  • Severe renal impairment


Advice From The Pharmacist

  • Patients should be educated about the injection technique and the importance of adhering to the dosing schedule to maintain therapeutic levels.
  • Regular follow-up appointments are necessary for monitoring effectiveness and any potential side effects.
  • Patients should be informed about the possibility of sedation and should avoid activities requiring alertness until they know how Invega Hafyera affects them.


Side Effects of Invega Hafyera

Common Side Effects

  • Weight gain
  • Drowsiness
  • Dizziness
  • Fatigue
  • Headache


Uncommon/Severe Side Effects

  • Extrapyramidal symptoms (e.g., tremors, rigidity)
  • Tardive dyskinesia (involuntary movements)
  • Neuroleptic malignant syndrome (NMS)


Risks and Warnings of Invega Hafyera

  • Metabolic Changes: Monitor for changes in weight, blood sugar, and lipid levels, as atypical antipsychotics can increase the risk of metabolic syndrome.
  • Cardiovascular Risks: Assess cardiovascular health, especially in patients with pre-existing conditions, as there may be an increased risk of stroke and cardiovascular events.
  • Elderly Patients: Use with caution in elderly patients with dementia-related psychosis, as there is an increased risk of death.


Interactions with Invega Hafyera

Common Drug Interactions

  • CNS Depressants: Caution is advised when combining Invega Hafyera with other medications that cause sedation or respiratory depression.
  • Medications that affect CYP450 enzymes: Invega Hafyera is primarily metabolized by CYP2D6; co-administration with inhibitors or inducers may affect plasma levels.


Alternatives to Invega Hafyera

  • Invega Sustenna: A monthly injectable formulation of paliperidone.
  • Risperidone: Another atypical antipsychotic that may be used for schizophrenia.
  • Olanzapine: An atypical antipsychotic with a different side effect profile.