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Inbrija
Inbrija (generic name: levodopa inhalation powder) is a prescription medication used for the treatment of off episodes in patients with Parkinson's disease who are already being treated with other dopaminergic medications. Inbrija is administered via an inhaler and provides a rapid-onset delivery of levodopa, a precursor to dopamine, which helps alleviate the symptoms of Parkinson's disease, such as rigidity, bradykinesia, and tremors.
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Frequently Asked Questions
How long does it take for Inbrija to work?
Patients may experience relief from symptoms within 10 to 30 minutes after inhalation.
Can Inbrija be used during pregnancy?
Inbrija should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Inbrija?
If you miss a dose during an off episode, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
t double up on doses. 4. Are there any special storage requirements for Inbrija?
Store Inbrija at room temperature, away from moisture and heat, and keep it in its original packaging until ready to use.
Is Inbrija safe for long-term use?
Inbrija can be used safely under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing off episodes.
Comprehensive Drug Guide
How Does Inbrija Work?
- Converting to dopamine: Once inhaled, levodopa is transported across the blood-brain barrier and converted into dopamine, which is deficient in individuals with Parkinson's disease.
- Restoring dopaminergic activity: By increasing dopamine levels in the brain, Inbrija helps improve motor function and reduce the severity of symptoms associated with Parkinson's disease.
Common Dosages
- Levodopa: 42 mg per inhalation. The recommended dose is 1 to 2 inhalations (42 mg to 84 mg) as needed for off episodes, with a maximum of 5 inhalations per day.
Typical Dosing
- Inhalation of 1 to 2 inhalations (42 mg to 84 mg) at the onset of an off episode. Patients should wait at least 1 hour before taking another dose.
Typical Dosing
FDA Approved Indications
- Treatment of off episodes in patients with Parkinson's disease who are taking other dopaminergic medications.
Who Shouldn't Take Inbrija?
- Known hypersensitivity to levodopa or any components of the formulation.
- Narrow-angle glaucoma or other contraindications to using dopaminergic therapy.
Advice From The Pharmacist
- Inbrija should be used only as directed for off episodes; it is not intended for the continuous treatment of Parkinson's disease.
- Inhale the medication as instructed to ensure proper delivery of the powder.
- Monitor for any side effects, especially any significant changes in mood or motor function, and report them to your healthcare provider.
Side Effects of Inbrija
Common Side Effects
- Cough
- Nausea
- Dizziness
- Headache
- Fatigue
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Hallucinations or other neuropsychiatric symptoms
- Dyskinesia (involuntary movements)
Risks and Warnings of Inbrija
- Pulmonary Effects: Patients with respiratory issues should be monitored closely, as inhalation of levodopa may exacerbate certain conditions.
- Neuropsychiatric Effects: Monitor for any changes in mood, behavior, or thought patterns; dosage adjustments may be necessary for those experiencing hallucinations or severe mood changes.
- Drug Interactions: Be aware of potential interactions with other medications used in the treatment of Parkinson's disease.
Interactions with Inbrija
Common Drug Interactions
- Dopaminergic medications: Care should be taken when using Inbrija with other dopaminergic agents, as this may increase the risk of side effects.
- MAOIs (Monoamine Oxidase Inhibitors): Concurrent use of Inbrija with MAOIs can lead to hypertensive crisis; caution is advised.
Alternatives to Inbrija
- Carbidopa-levodopa: The standard treatment for Parkinson's disease that provides a steady supply of levodopa.
- Dopamine agonists: Such as pramipexole or ropinirole, which stimulate dopamine receptors.
- COMT inhibitors: Such as entacapone, which can be used to extend the duration of effect of levodopa.
