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Inavix
Inavix (generic name: upadacitinib) is an oral Janus kinase (JAK) inhibitor used in the treatment of moderate to severe rheumatoid arthritis in adults. It works by blocking specific enzymes that contribute to the inflammatory process, thereby reducing inflammation, pain, and joint damage associated with rheumatoid arthritis. Inavix may also be prescribed for other autoimmune conditions, depending on the patient's needs and the healthcare provider's recommendations.
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Frequently Asked Questions
How long does it take for Inavix to start working?
Patients may start to see improvements in symptoms within 1 to 2 weeks, but optimal effects may take several weeks to develop.
Can Inavix be taken with other medications?
Yes, but it's important to discuss all medications and supplements you are taking with your healthcare provider to avoid potential interactions.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any long-term risks associated with Inavix?
Long-term use of Inavix can lead to increased risk of serious infections and blood clots. Regular monitoring by a healthcare provider is essential.
Is Inavix safe during pregnancy?
Inavix should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice regarding use during pregnancy.
Comprehensive Drug Guide
How Does Inavix Work?
- Reduce inflammation in the joints.
- Alleviate pain and improve function in patients with rheumatoid arthritis.
- Slow the progression of joint damage.
Common Dosages
- 15 mg taken orally once daily for the treatment of rheumatoid arthritis. Dosage may be adjusted based on response and tolerability.
Typical Dosing
- For rheumatoid arthritis: Start with 15 mg once daily. Based on clinical response and tolerability, the dose may be increased to 30 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment of moderate to severe rheumatoid arthritis in adults who have had an inadequate response to one or more disease-modifying antirheumatic drugs (DMARDs).
- It may also be used for other inflammatory conditions, such as atopic dermatitis and ulcerative colitis, depending on clinical judgment.
Who Shouldn't Take Inavix?
- Known hypersensitivity to upadacitinib or any components of the formulation.
- Active infections, including serious infections like tuberculosis, which may worsen during treatment.
Advice From The Pharmacist
- Take Inavix as prescribed, without regard to meals.
- Regular blood tests may be required to monitor liver function and blood cell counts due to potential side effects.
- Be aware of signs of infection, such as fever or cough, and report them to your healthcare provider immediately.
- Discuss all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
Side Effects of Inavix
Common Side Effects
- Nausea
- Headache
- Fatigue
- Upper respiratory infections
- Increased liver enzymes
Uncommon/Severe Side Effects
- Serious infections (e.g., tuberculosis, bacterial infections)
- Blood clots (deep vein thrombosis or pulmonary embolism)
- Elevated cholesterol levels
- Gastrointestinal perforations in patients with a history of diverticulitis
Risks and Warnings of Inavix
- Infection Risk: Inavix may increase the risk of serious infections; patients should be monitored for signs and symptoms of infections throughout treatment.
- Blood Clots: Caution should be exercised in patients with a history of thrombosis. Patients should be informed about the signs of blood clots, such as swelling, pain, or redness in the legs or sudden shortness of breath.
- Cholesterol Levels: Regular monitoring of lipid levels may be necessary, as JAK inhibitors can lead to elevated cholesterol.
Interactions with Inavix
Common Drug Interactions
- Immunosuppressants: Caution should be taken when using Inavix with other immunosuppressive agents, as this may increase the risk of infections.
- Live vaccines: Patients receiving Inavix should avoid live vaccines during treatment due to potential risks.
- CYP450 Enzyme Inhibitors/Inducers: Be aware of potential interactions with medications that affect the metabolism of Inavix.
Alternatives to Inavix
- Other JAK inhibitors: Such as tofacitinib (Xeljanz) or baricitinib (Olumiant) for similar indications.
- Biologics: Like adalimumab (Humira) or etanercept (Enbrel), which are also used to treat rheumatoid arthritis.
- Disease-modifying antirheumatic drugs (DMARDs): Such as methotrexate or sulfasalazine, used for long-term management of rheumatoid arthritis.
