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HYDROXYprogesterone Caproate
Hydroxyprogesterone Caproate is a synthetic progestin used primarily in obstetrics to reduce the risk of preterm birth in women who have a history of spontaneous preterm delivery. It helps to maintain pregnancy by inhibiting uterine contractions and supporting the uterine lining.
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Frequently Asked Questions
How quickly does Hydroxyprogesterone Caproate work?
The medication helps support pregnancy from the time of administration, but its effects on reducing preterm birth risk may not be immediately apparent.
Can I take Hydroxyprogesterone Caproate if I am pregnant?
Yes, it is specifically indicated for use during pregnancy to reduce the risk of preterm birth in at-risk women.
What should I do if I miss a dose?
If you miss a dose, contact your healthcare provider for instructions on when to administer the next dose.
Are there any specific storage instructions for Hydroxyprogesterone Caproate?
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Is Hydroxyprogesterone Caproate safe for long-term use?
It is generally used for a limited duration during pregnancy; long-term use outside of indicated situations should be monitored by a healthcare provider.
Comprehensive Drug Guide
How Does HYDROXYprogesterone Caproate Work?
Hydroxyprogesterone Caproate works by mimicking the action of natural progesterone, a hormone that plays a crucial role in maintaining pregnancy. It helps to relax the uterine muscles and prevent contractions, thereby reducing the risk of premature labor.
Common Dosages
- Injectable solution: Common concentration is 250 mg/mL.
Typical Dosing
The typical dosing for Hydroxyprogesterone Caproate is:
- For Preterm Birth Prevention: 250 mg administered by intramuscular injection once a week, starting between 16 and 20 weeks of gestation and continuing until 37 weeks of gestation.
Typical Dosing
FDA Approved Indications
- Prevention of preterm birth in women who have a history of spontaneous preterm delivery.
Who Shouldn't Take HYDROXYprogesterone Caproate?
- Hypersensitivity: Known hypersensitivity to hydroxyprogesterone or any components of the formulation.
- History of thromboembolic disorders: Such as deep vein thrombosis or pulmonary embolism.
- Active liver disease or liver tumors.
Advice From The Pharmacist
- How to Use: Hydroxyprogesterone Caproate should be administered by a healthcare provider. Ensure proper technique for intramuscular injections to minimize discomfort.
- Monitor for Side Effects: Patients should be monitored for signs of thromboembolic events, such as swelling, pain, or sudden shortness of breath.
- Regular Check-ups: Regular follow-up appointments are essential to monitor the effectiveness of the treatment and any potential side effects.
Side Effects of HYDROXYprogesterone Caproate
Common Side Effects
- Injection site reactions: Such as pain, swelling, or redness.
- Nausea or vomiting
- Headache
- Fatigue
Uncommon/Severe Side Effects
- Thromboembolic events: Such as blood clots, which can lead to pulmonary embolism or stroke.
- Severe allergic reactions: Such as rash, itching, or difficulty breathing.
Risks and Warnings of HYDROXYprogesterone Caproate
- Risk of Thrombosis: Patients should be advised of the increased risk of blood clots associated with progestin use.
- Monitor in High-Risk Patients: Use with caution in women with a history of cardiovascular disease, hypertension, or liver dysfunction.
Interactions with HYDROXYprogesterone Caproate
Common Drug Interactions
- Drug Interactions: Hydroxyprogesterone Caproate may interact with other medications that affect liver enzymes, including certain anticonvulsants and antibiotics. Always inform your healthcare provider about all medications you are taking.
Alternatives to HYDROXYprogesterone Caproate
- Other Progestins: Such as medroxyprogesterone acetate for various hormonal therapies.
- Cervical Cerclage: A surgical option for women with a history of cervical incompetence.
