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GoNitro
GoNitro (generic name: nitroglycerin) is a medication used primarily for the treatment of angina pectoris, which is chest pain resulting from reduced blood flow to the heart. It is also used for the management of acute heart failure and in certain cases of hypertension during surgery. GoNitro is classified as a nitrate, a type of vasodilator that works by relaxing and widening blood vessels, improving blood flow and oxygen delivery to the heart.
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Frequently Asked Questions
How long does it take for GoNitro to work?
GoNitro typically works within 1 to 3 minutes after administration for quick relief of angina symptoms.
Can GoNitro be taken during pregnancy?
GoNitro should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of GoNitro?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any special storage requirements for GoNitro?
Store GoNitro at room temperature, away from light and moisture, and keep the container tightly closed when not in use.
Is GoNitro safe for long-term use?
GoNitro can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing angina.
Comprehensive Drug Guide
How Does GoNitro Work?
- Releasing nitric oxide: Nitroglycerin is converted to nitric oxide in the body, which is a potent vasodilator.
- Vasodilation: The released nitric oxide relaxes smooth muscle in blood vessels, leading to dilation, which decreases the workload on the heart and reduces oxygen demand.
Common Dosages
- Sublingual tablets: Available in strengths of 0.3 mg, 0.6 mg, and 0.9 mg.
- Aerosol spray: Commonly 400 mcg per spray.
Typical Dosing
- For angina: Administer 1 tablet sublingually or 1 spray under the tongue at the onset of angina. If symptoms persist after 5 minutes, a second dose may be taken. If symptoms do not resolve after 15 minutes, seek emergency medical help.
Typical Dosing
FDA Approved Indications
- Prevention and treatment of angina pectoris
- Management of acute heart failure
- Treatment of hypertensive emergencies during surgery
Who Shouldn't Take GoNitro?
- Known hypersensitivity to nitroglycerin or any components of the formulation.
- Severe anemia or increased intracranial pressure.
- Use of phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil) within 24 to 48 hours, as this combination can cause severe hypotension.
Advice From The Pharmacist
- Take GoNitro at the first sign of angina; do not wait until the pain worsens.
- Keep the medication in its original container to protect it from light and moisture.
- Avoid alcohol consumption, as it can enhance the blood pressure-lowering effects and increase the risk of side effects.
- Be aware of potential side effects such as dizziness or headache, especially after the first few doses.
Side Effects of GoNitro
Common Side Effects
- Headache
- Dizziness or lightheadedness
- Flushing or warmth in the face
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, swelling, or difficulty breathing)
- Severe hypotension (extremely low blood pressure)
Risks and Warnings of GoNitro
- Hypotension: Monitor for symptoms of low blood pressure, especially if taking other medications that may lower blood pressure.
- Tolerance: Regular use of nitrates can lead to tolerance; therefore, a dosing regimen that allows for drug-free intervals may be necessary.
- Caution in certain populations: Patients with head trauma, cerebral hemorrhage, or severe liver or kidney impairment should use caution.
Interactions with GoNitro
Common Drug Interactions
- Phosphodiesterase-5 inhibitors: Concurrent use with drugs like sildenafil or tadalafil can cause dangerous drops in blood pressure.
- Other antihypertensives: Use with caution as it may potentiate their effects, leading to hypotension.
Alternatives to GoNitro
- Beta-blockers: Such as metoprolol or atenolol, which can also be used to manage angina and hypertension.
- Calcium channel blockers: Such as amlodipine or diltiazem, which may be effective in treating angina.
- Long-acting nitrates: Such as isosorbide mononitrate, for prevention of angina attacks.
