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Gocovri
Gocovri (generic name: amantadine) is a prescription medication used for the treatment of Parkinson's disease and to manage dyskinesia associated with this condition. It is particularly effective for patients who experience motor fluctuations while on other Parkinson's disease therapies. Gocovri is classified as an antiviral agent and is believed to work by increasing dopamine release and inhibiting its reuptake in the brain.
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Frequently Asked Questions
How long does it take for Gocovri to work?
Patients may begin to notice improvements in dyskinesia within weeks of starting treatment, although it may take longer for optimal effects.
Can Gocovri be taken during pregnancy?
Gocovri should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Gocovri?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Gocovri?
There are no specific dietary restrictions while taking Gocovri, but maintaining a healthy diet can support overall health.
Is Gocovri safe for long-term use?
Gocovri can be safe for long-term use under the supervision of a healthcare provider, with regular monitoring for potential side effects and effectiveness in managing dyskinesia.
Comprehensive Drug Guide
How Does Gocovri Work?
- Dopamine modulation: It enhances dopamine release and inhibits dopamine reuptake, increasing dopamine availability in the brain, which helps improve motor symptoms in Parkinson's disease.
- NMDA receptor antagonism: Amantadine also acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, which may contribute to its ability to reduce dyskinesia.
Common Dosages
- Amantadine: Extended-release capsules available in strengths of 68 mg and 137 mg.
Typical Dosing
- For dyskinesia in Parkinson's disease: The recommended starting dose is 137 mg once daily, typically taken at bedtime. The dose may be increased to a maximum of 274 mg once daily based on tolerance and clinical response.
Typical Dosing
FDA Approved Indications
- Treatment of dyskinesia in patients with Parkinson's disease who are already receiving levodopa-based therapy.
Who Shouldn't Take Gocovri?
- Known hypersensitivity to amantadine or any components of the formulation.
- Severe renal impairment (creatinine clearance < 15 mL/min), as dosage adjustments may be necessary.
Advice From The Pharmacist
- Take Gocovri as directed, typically once daily at bedtime, to help manage dyskinesia effectively.
- Avoid sudden discontinuation of the medication, as this may lead to a return of symptoms or other complications.
- Monitor for any signs of side effects, such as dizziness, confusion, or visual disturbances, and report them to your healthcare provider.
Side Effects of Gocovri
Common Side Effects
- Dizziness
- Dry mouth
- Nausea
- Fatigue
- Insomnia
Uncommon/Severe Side Effects
- Hallucinations or other significant changes in mental status
- Orthostatic hypotension (a drop in blood pressure upon standing)
- Severe allergic reactions (rash, itching, swelling, or difficulty breathing)
Risks and Warnings of Gocovri
- CNS Effects: Patients should be monitored for changes in mental status or mood, particularly during the initial stages of treatment or after dose adjustments.
- Renal Function: Regular monitoring of kidney function is recommended, especially in patients with pre-existing renal issues.
- Fall Risk: Dizziness or orthostatic hypotension may increase the risk of falls, particularly in elderly patients.
Interactions with Gocovri
Common Drug Interactions
- Other medications that affect the CNS: Caution should be exercised when using Gocovri with other CNS-active medications, as this may increase the risk of side effects.
- Anticholinergic drugs: Concurrent use may increase the risk of side effects like dry mouth and constipation.
Alternatives to Gocovri
- Other Parkinson's medications: Such as levodopa, dopamine agonists (e.g., pramipexole, ropinirole), or MAO-B inhibitors (e.g., rasagiline) may also be used to manage Parkinson's disease and associated symptoms.
- Deep brain stimulation: In certain cases, surgical options may be considered for managing dyskinesia and motor fluctuations.
