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Gabitril
Gabitril (tiagabine) is an anticonvulsant used to treat partial seizures in patients with epilepsy. It is often used as an adjunctive therapy alongside other seizure medications. Gabitril works by inhibiting the reuptake of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces nerve activity in the brain, helping to control seizures.
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Frequently Asked Questions
How long does it take for Gabitril to start working?
Gabitril may take several weeks to reach its full effect as the dose is gradually increased.
Can I drive while taking Gabitril?
Gabitril can cause drowsiness and dizziness, so avoid driving or operating heavy machinery until you know how the medication affects you.
What should I do if I miss a dose of Gabitril?
If you miss a dose, take it as soon as you remember unless it is close to the time of your next dose. Do not take two doses at once.
Can Gabitril cause weight gain?
Weight gain is not a common side effect of Gabitril, but some patients may experience changes in weight.
Is Gabitril safe for long-term use?
Yes, Gabitril can be used long-term for the management of epilepsy, but regular monitoring by your healthcare provider is recommended.
Comprehensive Drug Guide
How Does Gabitril Work?
Gabitril works by blocking the reuptake of GABA, a neurotransmitter that reduces the excitability of neurons in the brain. By increasing the levels of GABA, Gabitril helps prevent the excessive electrical activity that leads to seizures.
Common Dosages
- Tablets: 2 mg, 4 mg, 12 mg, 16 mg
7. Typical Dosing
- The typical starting dose for Gabitril is 4 mg once daily, which may be increased by 4 to 8 mg per week until the desired effect is achieved. The maintenance dose ranges from 32 to 56 mg per day, divided into two to four doses.
Typical Dosing
FDA Approved Indications
- Adjunctive therapy for partial seizures in patients with epilepsy aged 12 years and older.
Who Shouldn't Take Gabitril?
- Known hypersensitivity to tiagabine or any of its components.
- Liver disease, as Gabitril is metabolized in the liver and may require dosage adjustments.
Advice From The Pharmacist
- Take Gabitril with food to reduce the risk of stomach upset.
- Do not stop taking Gabitril suddenly, as this may cause increased seizures. Gradual tapering is recommended under medical supervision.
- Avoid alcohol while taking Gabitril, as it may increase drowsiness and the risk of seizures.
Side Effects of Gabitril
Common Side Effects
- Dizziness
- Drowsiness
- Tremor
- Difficulty concentrating
Uncommon/Severe Side Effects
- Worsening of seizures
- Suicidal thoughts or behavior
Risks and Warnings of Gabitril
- Seizure Risk: Gabitril may increase the risk of seizures, especially if used in patients who do not have epilepsy.
- Suicidal Thoughts: Gabitril, like other anticonvulsants, may increase the risk of suicidal thoughts and behaviors. Patients should be monitored for changes in mood or behavior.
Interactions with Gabitril
Common Drug Interactions
- CNS depressants: Concurrent use of Gabitril with other central nervous system depressants, such as alcohol or benzodiazepines, may increase the risk of drowsiness and impaired motor coordination.
Alternatives to Gabitril
- Keppra (levetiracetam)
- Lamictal (lamotrigine)
- Topamax (topiramate)
