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Fragmin
Fosamax (generic name: alendronate sodium) is a bisphosphonate medication used to treat and prevent osteoporosis in postmenopausal women, as well as in men and individuals taking corticosteroids. It works by slowing down the process of bone breakdown, allowing the bone to strengthen and increase in density, thereby reducing the risk of fractures.
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Frequently Asked Questions
How long does it take for Fragmin to start working?
Fragmin works quickly, typically within 1 hour of injection.
Can I take Fragmin at home?
Yes, your healthcare provider may train you to self-administer Fragmin at home via subcutaneous injection.
What should I do if I miss a dose?
If you miss a dose of Fragmin, take it as soon as you remember, but do not double the dose. Contact your healthcare provider if you are unsure.
Can I have surgery while taking Fragmin?
Surgery or dental procedures may need special planning while on Fragmin. Inform your surgeon or dentist that you are on an anticoagulant.
Does Fragmin have to be refrigerated?
No, Fragmin can be stored at room temperature. Keep it away from direct sunlight and heat.
Comprehensive Drug Guide
How Does Fragmin Work?
Fosamax inhibits osteoclast-mediated bone resorption, which helps to slow down bone loss and improve bone mineral density, reducing the risk of fractures in patients with osteoporosis.
Common Dosages
- 35 mg and 70 mg oral tablets (weekly)
- 10 mg oral tablets (daily)
- 70 mg/75 mL oral solution
Typical Dosing
- For osteoporosis, the typical dose is 70 mg once weekly or 10 mg once daily.
Typical Dosing
FDA Approved Indications
- Treatment and prevention of osteoporosis in postmenopausal women
- Osteoporosis in men
- Glucocorticoid-induced osteoporosis
- Paget’s disease of bone
Who Shouldn't Take Fragmin?
- Hypocalcemia (low calcium levels)
- Inability to remain upright for 30 minutes
- Esophageal abnormalities that delay emptying
Advice From The Pharmacist
- Take Fosamax first thing in the morning with a full glass of water, at least 30 minutes before eating, drinking, or taking other medications.
- Remain upright (sitting or standing) for at least 30 minutes after taking Fosamax to prevent irritation of the esophagus.
- Ensure adequate intake of calcium and vitamin D to support bone health.
Side Effects of Fragmin
Common Side Effects
- Gastrointestinal discomfort (heartburn, nausea)
- Musculoskeletal pain
- Headache
Uncommon/Severe Side Effects
- Esophageal ulcers
- Osteonecrosis of the jaw
- Atypical femur fractures
Risks and Warnings of Fragmin
- Esophageal Irritation: Fosamax can cause esophageal irritation and ulcers. Follow administration instructions carefully to avoid these side effects.
- Osteonecrosis of the Jaw: Rare cases of jawbone deterioration have been reported, especially after dental procedures. Notify your dentist that you are taking Fosamax.
Interactions with Fragmin
Common Drug Interactions
- Calcium supplements or antacids: These can interfere with the absorption of Fosamax. Take them at least 30 minutes after taking Fosamax.
- NSAIDs: Using Fosamax with NSAIDs (e.g., ibuprofen) can increase the risk of gastrointestinal irritation.
Alternatives to Fragmin
- Boniva (ibandronate): Another bisphosphonate used for osteoporosis.
- Prolia (denosumab): A biologic medication used to treat osteoporosis in high-risk patients.
- Reclast (zoledronic acid): An injectable bisphosphonate used to treat osteoporosis.
