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Fosfomycin Tromethamine
Fosfomycin Tromethamine is an antibiotic used to treat uncomplicated urinary tract infections (UTIs) caused by certain bacteria. It is a broad-spectrum antibiotic that inhibits bacterial cell wall synthesis, leading to the death of the bacteria. Fosfomycin Tromethamine is typically administered as a single-dose oral granule, making it a convenient option for treating UTIs.
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Frequently Asked Questions
How long does Fosfomycin Tromethamine take to work?
Fosfomycin Tromethamine is typically effective within a few days. If symptoms persist or worsen, contact your healthcare provider.
Can I take Fosfomycin Tromethamine with other medications?
Inform your healthcare provider about all other medications you are taking, as Fosfomycin may interact with certain drugs.
What should I do if I miss a dose?
Fosfomycin Tromethamine is usually taken as a single dose, so missing a dose typically isn’t a concern. Contact your healthcare provider for guidance.
Are there any dietary restrictions while taking Fosfomycin Tromethamine?
No specific dietary restrictions are required, but it is important to follow the instructions for mixing the powder with water.
Comprehensive Drug Guide
How Does Fosfomycin Tromethamine Work?
Fosfomycin Tromethamine works by inhibiting MurA enzyme, which is essential for bacterial cell wall synthesis. By blocking this enzyme, Fosfomycin disrupts the formation of the bacterial cell wall, leading to the death of the bacteria and resolving the infection.
Common Dosages
- Oral powder for reconstitution: 3 grams per dose
Typical Dosing
The typical dosing for Fosfomycin Tromethamine is:
- For uncomplicated UTIs: A single dose of 3 grams mixed with water, taken orally.
Typical Dosing
FDA Approved Indications
Uncomplicated urinary tract infections (UTIs) caused by susceptible strains of bacteria
Who Shouldn't Take Fosfomycin Tromethamine?
- Hypersensitivity: Patients with a known hypersensitivity to Fosfomycin or any of its components.
- Severe renal impairment: Patients with creatinine clearance less than 10 mL/min should avoid using this medication unless advised by a healthcare provider.
Advice From The Pharmacist
- Administration: Mix the entire contents of the packet with 3-4 ounces of water and drink immediately. Do not use any other liquids for mixing.
- Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements.
- Hydration: Maintain adequate hydration to support urinary tract health.
- Consulting Healthcare Providers: Contact your healthcare provider if symptoms of the infection do not improve or worsen after taking the medication.
Side Effects of Fosfomycin Tromethamine
Common Side Effects
- Gastrointestinal symptoms: Nausea, diarrhea, and abdominal pain.
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Allergic reactions: Rash, itching, or swelling.
- Severe gastrointestinal symptoms: Persistent diarrhea or bloody stools.
Risks and Warnings of Fosfomycin Tromethamine
- Allergic Reactions: Patients should be monitored for signs of an allergic reaction, which may require discontinuation of the medication.
- Renal Impairment: Use with caution in patients with severe renal impairment.
- Superinfection: Prolonged use may result in the overgrowth of non-susceptible bacteria or fungi.
Interactions with Fosfomycin Tromethamine
Common Drug Interactions
- Antacids: May reduce the absorption of Fosfomycin. Separate doses by at least 2 hours.
- Other antibiotics: Use with caution if taking other antibiotics to avoid potential interactions.
Alternatives to Fosfomycin Tromethamine
- Nitrofurantoin: A commonly used antibiotic for UTIs.
- Trimethoprim-Sulfamethoxazole (TMP-SMX): Another option for UTI treatment.
- Cephalexin: A cephalosporin antibiotic used for UTIs.
