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Fluvastatin Sodium ER
Fluvastatin Sodium ER (extended-release) is a statin used to manage hyperlipidemia (high cholesterol) and to reduce the risk of cardiovascular events, such as heart attacks and strokes. It works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis in the liver. By lowering cholesterol levels, Fluvastatin helps to prevent the buildup of plaque in the arteries and reduce the risk of heart disease.
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Frequently Asked Questions
How long does it take to see results from Fluvastatin Sodium ER?
It may take several weeks to see the full effects on cholesterol levels. Regular monitoring will help assess the effectiveness of the treatment.
Can I drink alcohol while taking Fluvastatin Sodium ER?
Moderate alcohol consumption is generally considered safe, but excessive alcohol can increase the risk of liver issues. Discuss your alcohol intake with your healthcare provider.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double up on doses to make up for a missed one.
Are there any specific dietary restrictions while taking Fluvastatin Sodium ER?
There are no specific dietary restrictions, but a healthy diet low in saturated fats and cholesterol can enhance the effectiveness of the medication. Avoid large amounts of grapefruit juice.
Comprehensive Drug Guide
How Does Fluvastatin Sodium ER Work?
Fluvastatin Sodium ER works by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver. By blocking this enzyme, Fluvastatin reduces the levels of low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. This action helps prevent the formation of atherosclerotic plaques and reduces the risk of cardiovascular diseases.
Common Dosages
- Extended-release tablets: 80 mg
Typical Dosing
The typical dosing for Fluvastatin Sodium ER is:
- For Hyperlipidemia: The usual starting dose is 80 mg once daily, taken in the evening. The dose may be adjusted based on lipid levels and patient response, with a maximum dose of 80 mg per day.
Typical Dosing
FDA Approved Indications
- Primary hyperlipidemia (high cholesterol) and mixed dyslipidemia (elevated cholesterol and triglycerides)
- Prevention of cardiovascular events in patients at risk for heart disease, including those with coronary artery disease or other risk factors
Who Shouldn't Take Fluvastatin Sodium ER?
- Hypersensitivity: Patients with a known hypersensitivity to fluvastatin or any of its components.
- Active Liver Disease: Patients with active liver disease or unexplained persistent elevations in liver enzymes.
- Pregnancy and Breastfeeding: Pregnant or breastfeeding women should avoid using this medication due to potential risks to the fetus or infant.
Advice From The Pharmacist
- Administration: Take Fluvastatin Sodium ER once daily in the evening with or without food. Do not crush or chew the tablets.
- Interactions: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements. Avoid consuming large amounts of grapefruit or grapefruit juice, as it can increase the risk of side effects.
- Monitoring: Regularly check your cholesterol levels and liver function as directed by your healthcare provider. Report any unexplained muscle pain, tenderness, or weakness.
Side Effects of Fluvastatin Sodium ER
Common Side Effects
- Headache
- Digestive issues (e.g., nausea, diarrhea, abdominal pain)
- Muscle pain or weakness
Uncommon/Severe Side Effects
- Liver problems (e.g., jaundice, dark urine)
- Severe muscle problems (e.g., rhabdomyolysis)
Risks and Warnings of Fluvastatin Sodium ER
- Liver Function: Regular monitoring of liver function is essential due to the risk of liver damage.
- Muscle Issues: Watch for signs of muscle pain or weakness, which could indicate a serious condition called rhabdomyolysis.
- Drug Interactions: Be cautious of interactions with other medications, which can increase the risk of side effects.
Interactions with Fluvastatin Sodium ER
Common Drug Interactions
- Other statins or cholesterol-lowering medications
- Certain antibiotics (e.g., erythromycin)
- Antifungal medications (e.g., itraconazole)
- Grapefruit juice (can increase the risk of side effects)
Alternatives to Fluvastatin Sodium ER
- Other statins (e.g., atorvastatin, simvastatin, rosuvastatin)
- Non-statin options (e.g., ezetimibe, niacin, fibrates)
- PCSK9 inhibitors (e.g., alirocumab, evolocumab)
