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fentaNYL Citrate (PF)

FentaNYL Citrate (PF) refers to fentanyl citrate (Preservative-Free), a potent opioid analgesic used for managing severe pain, especially in patients requiring continuous pain control, such as those with cancer, or in acute settings like surgical anesthesia. FentaNYL Citrate works by binding to opioid receptors in the brain and spinal cord, significantly altering the body’s pain perception. The preservative-free formulation is commonly used in specialized settings like epidural or intravenous administration where sterility and the absence of preservatives are crucial.



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Frequently Asked Questions

How long does it take for FentaNYL Citrate (PF) to start working?
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FentaNYL starts working within minutes when administered via IV. Its effects may last for 30 minutes to several hours, depending on the dose and administration route.

Can FentaNYL Citrate (PF) be used for long-term pain management?
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Yes, fentanyl can be used for chronic pain management in opioid-tolerant patients, particularly in severe cancer pain or palliative care settings. However, it is crucial to monitor for signs of dependence and side effects.

What should I do if I miss a dose of FentaNYL?
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FentaNYL Citrate (PF) is typically administered in a hospital setting under professional supervision, so missed doses are uncommon. For chronic pain management in outpatient settings, follow your healthcare provider’s instructions carefully.

Can I use FentaNYL if I have respiratory issues?
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FentaNYL Citrate (PF) is contraindicated in patients with severe respiratory depression. Patients with asthma or COPD should use fentanyl with extreme caution and only under close medical supervision.

How is FentaNYL Citrate (PF) different from regular fentanyl?
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FentaNYL Citrate (PF) refers to the preservative-free formulation, which is specifically used for injections, infusions, or epidurals in settings where sterility and the absence of preservatives are important, such as surgery or epidural pain relief.

Comprehensive Drug Guide

How Does fentaNYL Citrate (PF) Work?

FentaNYL Citrate (PF) works by binding to mu-opioid receptors in the brain, spinal cord, and other parts of the body. This binding alters the transmission of pain signals, effectively reducing the sensation of pain. FentaNYL is much more potent than other opioids like morphine, meaning smaller doses are needed to achieve similar effects.



Common Dosages

FentaNYL Citrate (PF) is dosed based on the patient’s opioid tolerance, the severity of pain, and the setting in which it is used:

  • For severe pain management: Initial doses may range from 50 mcg to 100 mcg administered via intravenous or epidural infusion, with doses adjusted based on patient response.
  • For anesthesia: FentaNYL doses may vary from 50 mcg to 100 mcg or higher, depending on the depth of anesthesia required.

Typical Dosing

FDA Approved Indications

  • Severe chronic pain in opioid-tolerant patients.
  • Breakthrough cancer pain in opioid-tolerant patients.
  • Anesthesia (as part of surgical anesthesia).
  • Postoperative pain management.
  • Epidural and intrathecal pain management in certain cases.

Who Shouldn't Take fentaNYL Citrate (PF)?

  • Opioid-naïve patients, due to the high risk of respiratory depression.
  • Patients with significant respiratory depression, especially those without access to ventilatory support.
  • Patients with severe asthma or other conditions causing severe breathing issues.
  • Known hypersensitivity to fentanyl or other opioids.

Advice From The Pharmacist

  • FentaNYL Citrate (PF) should only be used by trained healthcare professionals in a hospital or specialized setting where monitoring is possible.
  • Do not use in opioid-naïve patients, as fentanyl can cause fatal respiratory depression.
  • Monitor for signs of overdose, including shallow breathing, extreme drowsiness, or loss of consciousness.
  • Dispose of unused doses properly, especially in outpatient settings, to avoid accidental exposure or misuse.

Side Effects of fentaNYL Citrate (PF)

Common Side Effects

  • Drowsiness or sedation
  • Dizziness
  • Nausea and vomiting
  • Constipation
  • Sweating


Uncommon/Severe Side Effects

  • Severe respiratory depression or breathing difficulties, which can be life-threatening.
  • Bradycardia (slow heart rate).
  • Hypotension (low blood pressure).
  • Addiction, abuse, and dependence.
  • Serotonin syndrome when used with serotonergic drugs (symptoms include agitation, confusion, rapid heartbeat).

Risks and Warnings of fentaNYL Citrate (PF)

  • Respiratory Depression: FentaNYL Citrate (PF) has a high risk of respiratory depression, which can be fatal, especially when used in high doses or in patients without opioid tolerance.
  • Abuse and Dependence: FentaNYL is a Schedule II controlled substance and has a high potential for abuse, leading to addiction or dependence.
  • Accidental Exposure: FentaNYL is extremely potent, and even small amounts can cause overdose, especially in children or opioid-naïve individuals. Proper storage and disposal are crucial.
  • Serotonin Syndrome: Risk increases when used with SSRIs, SNRIs, or other drugs affecting serotonin levels.

Interactions with fentaNYL Citrate (PF)

Common Drug Interactions

  • Benzodiazepines and CNS depressants: Combining fentanyl with benzodiazepines (e.g., diazepam) or other central nervous system depressants increases the risk of respiratory depression.
  • MAO inhibitors: FentaNYL should not be used with MAO inhibitors due to the risk of severe, life-threatening interactions.
  • Serotonergic drugs (SSRIs, SNRIs, tricyclic antidepressants): These can increase the risk of serotonin syndrome when combined with fentanyl.
  • Alcohol: Should be avoided while using fentanyl due to the increased risk of sedation, dizziness, and respiratory depression.

Alternatives to fentaNYL Citrate (PF)

  • Morphine: Another opioid analgesic often used for severe pain management.
  • Hydromorphone (Dilaudid): A potent opioid used for moderate to severe pain.
  • Methadone: Another long-acting opioid used for pain relief and sometimes for opioid dependence.
  • Oxycodone: A commonly used opioid for moderate to severe pain management.