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Ezetimibe-Rosuvastatin

Ezetimibe-Rosuvastatin is a combination medication used to lower cholesterol and triglycerides in the blood. It combines ezetimibe, which reduces the absorption of cholesterol from the intestines, and rosuvastatin, a statin that lowers cholesterol production in the liver. This dual-action therapy is typically prescribed to patients with hypercholesterolemia or mixed dyslipidemia to reduce the risk of cardiovascular diseases such as heart attack and stroke.



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Frequently Asked Questions

How long does it take for Ezetimibe-Rosuvastatin to work? .
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Ezetimibe-Rosuvastatin typically begins lowering cholesterol levels within 1 to 2 weeks of starting treatment. However, it may take up to 4 weeks to see the full effect

Can I take Ezetimibe-Rosuvastatin if I have liver problems?
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This medication is not recommended for patients with active liver disease or persistent elevations in liver enzymes. Regular monitoring of liver function is required during treatment.

What should I do if I miss a dose of Ezetimibe-Rosuvastatin?
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If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

Can Ezetimibe-Rosuvastatin cause muscle pain?
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Yes, muscle pain or weakness is a potential side effect of rosuvastatin, particularly at higher doses or in combination with certain medications. If you experience these symptoms, contact your healthcare provider.

Can I drink alcohol while taking Ezetimibe-Rosuvastatin?
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Alcohol should be consumed with caution while taking this medication, as it can increase the risk of liver damage, especially in combination with rosuvastatin. Consult your doctor regarding alcohol consumption.

Comprehensive Drug Guide

How Does Ezetimibe-Rosuvastatin Work?

  • Ezetimibe reduces the absorption of cholesterol from the intestines, which decreases the amount of cholesterol entering the bloodstream.
  • Rosuvastatin inhibits HMG-CoA reductase, an enzyme responsible for cholesterol production in the liver, leading to a decrease in low-density lipoprotein (LDL) cholesterol and an increase in high-density lipoprotein (HDL) cholesterol.

Common Dosages

The dosage of Ezetimibe-Rosuvastatin depends on the patient’s cholesterol levels and risk factors:

  • The typical starting dose is 10 mg/10 mg once daily (10 mg of ezetimibe and 10 mg of rosuvastatin).
  • Doses can range up to 10 mg/40 mg once daily based on the patient’s response and tolerability.

Typical Dosing

FDA Approved Indications

  • Primary hyperlipidemia: To reduce elevated LDL cholesterol, total cholesterol, and triglycerides.
  • Mixed dyslipidemia: To manage elevated LDL cholesterol and triglycerides while increasing HDL cholesterol.
  • Prevention of cardiovascular events: For patients at high risk of heart disease.

Who Shouldn't Take Ezetimibe-Rosuvastatin?

  • Known hypersensitivity to ezetimibe, rosuvastatin, or any components of the formulation.
  • Active liver disease or unexplained, persistent elevations in liver enzymes.
  • Pregnancy or breastfeeding, as statins are contraindicated during pregnancy due to the risk of fetal harm.

Advice From The Pharmacist

  • Take Ezetimibe-Rosuvastatin at the same time every day, with or without food.
  • Avoid consuming grapefruit or grapefruit juice while taking this medication, as it can increase the risk of side effects related to rosuvastatin.
  • Do not stop taking the medication suddenly without consulting your healthcare provider, as this may increase cholesterol levels.
  • Routine blood tests to monitor liver function and cholesterol levels are recommended while taking this medication.
  • Alcohol should be consumed with caution, as it can increase the risk of liver damage.

Side Effects of Ezetimibe-Rosuvastatin

Common Side Effects

  • Headache
  • Muscle pain
  • Fatigue
  • Nausea
  • Diarrhea


Uncommon/Severe Side Effects

  • Muscle problems (myopathy, rhabdomyolysis) characterized by muscle pain, weakness, or tenderness, especially in combination with fatigue or dark urine.
  • Liver damage (yellowing of the skin or eyes, dark urine, severe fatigue).
  • Kidney problems (swelling, reduced urination).
  • Severe allergic reactions (rash, swelling, difficulty breathing).

Risks and Warnings of Ezetimibe-Rosuvastatin

  • Myopathy and Rhabdomyolysis: Rosuvastatin can cause muscle damage, which may lead to a serious condition called rhabdomyolysis. Patients should report any unexplained muscle pain, tenderness, or weakness to their healthcare provider.
  • Liver Toxicity: Both ezetimibe and rosuvastatin may cause liver damage, so regular liver function tests are recommended.
  • Renal Impairment: Rosuvastatin can affect kidney function, especially at higher doses. Dosage adjustments may be required in patients with kidney disease.
  • Pregnancy: Rosuvastatin is contraindicated during pregnancy due to the risk of fetal harm. Women of childbearing age should use effective contraception while taking this medication.

Interactions with Ezetimibe-Rosuvastatin

Common Drug Interactions

  • Cyclosporine: May increase the levels of both ezetimibe and rosuvastatin, leading to a higher risk of side effects.
  • Antacids containing aluminum or magnesium: Can reduce the absorption of rosuvastatin; take antacids at least 2 hours after Ezetimibe-Rosuvastatin.
  • Warfarin: Rosuvastatin may increase the effect of warfarin, leading to a higher risk of bleeding.
  • Gemfibrozil: This combination may increase the risk of muscle-related side effects.

Alternatives to Ezetimibe-Rosuvastatin

  • Atorvastatin/Ezetimibe (Liptruzet): A similar combination medication used to lower cholesterol and reduce the risk of cardiovascular events.
  • Simvastatin/Ezetimibe (Vytorin): Another statin/ezetimibe combination used for cholesterol management.
  • Atorvastatin (Lipitor): A standalone statin commonly prescribed for lowering cholesterol.
  • Pravastatin (Pravachol): A statin that may be less likely to interact with other medications.
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