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Estazolam

Estazolam, sold under the brand name ProSom, is a benzodiazepine used for the short-term treatment of insomnia. It helps patients fall asleep and stay asleep by enhancing the effects of GABA (a neurotransmitter that promotes relaxation). Estazolam is typically used for short-term relief of sleep disorders due to its potential for dependence.



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Frequently Asked Questions

How long does it take for Estazolam to work?
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Estazolam typically takes effect within 30 minutes to an hour after taking it.

Can Estazolam be used long-term?
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No, Estazolam is intended for short-term use only due to the risk of dependence and withdrawal symptoms.

Can I stop taking Estazolam suddenly?
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No, Estazolam should be tapered off gradually under medical supervision to avoid withdrawal symptoms.

Does Estazolam cause next-day drowsiness?
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Yes, Estazolam may cause drowsiness the next day, especially if taken late at night or if higher doses are used.

Is Estazolam safe for older adults?
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Older adults may be more sensitive to the sedative effects of Estazolam, which increases the risk of falls and confusion. Lower doses or alternative treatments may be recommended.

Comprehensive Drug Guide

How Does Estazolam Work?

Estazolam works by enhancing the activity of GABA, a neurotransmitter that inhibits brain activity and promotes relaxation. This helps induce sleep and prolongs its duration, making it effective for managing insomnia.



Common Dosages

  • Tablets: 1 mg, 2 mg

Typical Dosing

  • The typical dose for insomnia is 1 mg to 2 mg taken at bedtime. The dose may be adjusted based on patient response, but it is generally used for short-term therapy (7 to 10 days).



Typical Dosing

FDA Approved Indications

  • Short-term treatment of insomnia


Who Shouldn't Take Estazolam?

  • Known hypersensitivity to estazolam or other benzodiazepines.
  • Severe liver disease or respiratory disorders.


Advice From The Pharmacist

  • Take Estazolam just before bedtime, as it may cause drowsiness and impair your ability to perform tasks that require full attention.
  • Avoid alcohol while taking Estazolam, as it can increase sedative effects.
  • Estazolam is for short-term use only due to the risk of dependence.


Side Effects of Estazolam

Common Side Effects

  • Drowsiness
  • Dizziness
  • Headache
  • Next-day grogginess


Uncommon/Severe Side Effects

  • Memory problems
  • Severe allergic reactions
  • Respiratory depression


Risks and Warnings of Estazolam

  • Dependence Risk: Long-term use of Estazolam can lead to physical and psychological dependence. It should be used for short periods only.
  • Withdrawal Symptoms: Abrupt discontinuation may lead to withdrawal symptoms, including seizures, anxiety, and insomnia.


Interactions with Estazolam

Common Drug Interactions

  • Alcohol: Alcohol can enhance the sedative effects of Estazolam, leading to increased drowsiness and impaired motor function.
  • CNS depressants: Other central nervous system depressants, including opioids, may increase the risk of sedation and respiratory depression when combined with Estazolam.


Alternatives to Estazolam

  • Ambien (zolpidem)
  • Lunesta (eszopiclone)
  • Temazepam (Restoril)