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Erythromycin Ethylsuccinate
Erythromycin Ethylsuccinate is a macrolide antibiotic used to treat a variety of bacterial infections. It works by inhibiting bacterial protein synthesis, helping to stop the growth of bacteria. Erythromycin ethylsuccinate is commonly used to treat respiratory tract infections, skin infections, ear infections, and certain sexually transmitted infections (STIs). It is often prescribed for patients allergic to penicillin and is also effective against certain gram-positive and gram-negative bacteria.
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Frequently Asked Questions
Can I take Erythromycin Ethylsuccinate with food?
Yes, erythromycin ethylsuccinate can be taken with food to reduce the likelihood of stomach upset.
How long does it take for Erythromycin Ethylsuccinate to work?
You should start to feel better within a few days of starting erythromycin ethylsuccinate. However, you must complete the full course of treatment even if symptoms improve to avoid antibiotic resistance.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
Can I take Erythromycin Ethylsuccinate if I am pregnant?
Erythromycin is generally considered safe during pregnancy. However, consult your healthcare provider to discuss the risks and benefits based on your specific circumstances.
Is Erythromycin Ethylsuccinate safe for children?
Yes, erythromycin ethylsuccinate is safe for children when used in the appropriate doses based on weight and infection type. Always follow the healthcare provider’s instructions for pediatric dosing.
Comprehensive Drug Guide
How Does Erythromycin Ethylsuccinate Work?
Erythromycin ethylsuccinate works by binding to the 50S ribosomal subunit of bacterial cells, inhibiting protein synthesis. This action stops the growth of bacteria, allowing the immune system to eliminate the infection. It is considered a bacteriostatic antibiotic, meaning it prevents bacteria from multiplying but does not necessarily kill them outright.
Common Dosages
The typical dosage of erythromycin ethylsuccinate depends on the type and severity of the infection:
- Adults: 400 mg every 6 to 8 hours, or 800 mg every 12 hours.
- Children: 30-50 mg/kg/day divided into multiple doses, depending on the child’s weight and infection severity.
Typical Dosing
- Adults: The standard dose is 400 mg every 6 hours for mild to moderate infections. In severe cases, the dose can be increased to 800 mg every 6 to 8 hours.
- Children: Dosing is typically based on weight, with 30-50 mg/kg/day divided into 4 doses daily.
Typical Dosing
FDA Approved Indications
- Respiratory tract infections (e.g., bronchitis, pneumonia)
- Skin and soft tissue infections
- Ear infections (e.g., otitis media)
- Strep throat
- Whooping cough (pertussis)
- Sexually transmitted infections (e.g., chlamydia)
- Diphtheria
Who Shouldn't Take Erythromycin Ethylsuccinate?
- Hypersensitivity to erythromycin or other macrolide antibiotics
- Severe liver dysfunction or a history of liver damage caused by erythromycin
- Myasthenia gravis (may exacerbate muscle weakness)
Advice From The Pharmacist
- Erythromycin ethylsuccinate can be taken with or without food, although taking it with food may reduce stomach upset.
- Shake the oral suspension well before each use to ensure proper mixing.
- Complete the full course of antibiotics as prescribed, even if symptoms improve before finishing the medication. Stopping early may cause the infection to return or develop resistance.
- Store the oral suspension in the refrigerator and discard any unused portion after 10 days.
Side Effects of Erythromycin Ethylsuccinate
Common Side Effects
- Nausea
- Diarrhea
- Stomach pain or cramping
- Vomiting
Uncommon/Severe Side Effects
- Liver dysfunction (jaundice, dark urine, upper abdominal pain)
- Allergic reactions (hives, difficulty breathing, swelling)
- Hearing loss (especially with prolonged use or high doses)
- QT prolongation (irregular heart rhythm)
Risks and Warnings of Erythromycin Ethylsuccinate
- QT Prolongation: Erythromycin can prolong the QT interval, increasing the risk of serious heart arrhythmias, particularly in individuals with pre-existing heart conditions or when taken with other QT-prolonging medications.
- Liver Toxicity: Erythromycin ethylsuccinate has been linked to liver damage, particularly in patients with pre-existing liver conditions. If signs of liver dysfunction occur, such as yellowing of the skin or eyes, discontinue the drug and seek medical attention.
- Hearing Loss: High doses or prolonged use of erythromycin, especially in elderly patients or those with kidney impairment, may result in reversible or permanent hearing loss.
Interactions with Erythromycin Ethylsuccinate
Common Drug Interactions
- Statins: Erythromycin can increase the risk of rhabdomyolysis (muscle damage) when taken with statins like atorvastatin or simvastatin.
- Warfarin: Erythromycin may enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
- Theophylline: Erythromycin may elevate blood levels of theophylline, leading to an increased risk of side effects such as nausea and vomiting.
- QT-prolonging drugs: Combining erythromycin with medications that prolong the QT interval, such as amiodarone or sotalol, can increase the risk of dangerous heart arrhythmias.
Alternatives to Erythromycin Ethylsuccinate
- Azithromycin: Another macrolide antibiotic with less frequent dosing and a longer half-life.
- Clindamycin: A lincosamide antibiotic used for similar infections, particularly in patients allergic to macrolides.
- Amoxicillin: A penicillin-class antibiotic commonly used for respiratory and skin infections, particularly in patients without a penicillin allergy.
